Project description
Linking sleep patterns with neurodegeneration
Idiopathic rapid eye movement (REM) sleep behaviour disorder (iRBD) manifests as unpleasant dreams and dream-enacting behaviour during sleep. Patients have an increased risk of developing Parkinson’s disease (PD) with common pathophysiology features such as protein deposition in the brain. The scope of the EU-funded Sleep_PD-RBD project is to characterise changes during wake and sleep modes in iRBD patients. For this purpose, scientists will use retrospective databases of patients and correlate EEG observations with sleep disturbances and gastrointestinal symptoms. Results will unveil important aspects of the neurodegeneration process and the gut–brain axis in disease aetiology.
Objective
Idiopathic REM sleep Behavior Disorder (iRBD), a condition characterized by abnormal behaviors during sleep associated with dream enactment, is considered a prodromal state of Parkinson’s disease (PD). Both disorders share a common pathophysiology consisting of abnormal protein deposition from the gastrointestinal tract to the brain via ascending pathways. Whereas motor aspects have been extensively studied in iRBD/PD, a comprehensive view of the effects of the pathology on sleep-wake microarchitecture is still lacking. This Sleep_PD-RBD project focuses on the sleep disturbances associated with iRBD/PD and what they may reveal about the neurodegenerative process. Besides characterizing alterations in vigilance state regulation and sleep oscillations, I will correlate these EEG observations to gastrointestinal symptoms and daytime sleepiness, which both greatly impair patients’ quality of life. The original aspect of this project consist of studying sleep alterations with the recent concept of sleep and wake as non-mutually exclusive states, emphasizing sleep-wake dynamics as opposed to sleep scoring with conventional polysomnography variables, and with innovative EEG analyses investigating the properties of specific sleep oscillations and their cross-coupling. The project also links the brain to the guts, a current hot research topic. This multi-disciplinary project will rely on retrospective databases of patients obtained in Lyon and collaborative centers across France, as well as ongoing recruitment of patients and controls. For this project, I will benefit from the strong expertise of the Lyon Neuroscience Research Center in neuroscience research and of the Center for Sleep Medicine and Respiratory Diseases of Lyon University Hospital for clinical research aspects. With this fellowship, I aim to reintegrate the French academic network in an ideal research setting to learn technical and team-leadership skills and grow into a qualified independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry sleep disorders
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology parkinson
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.