Activating neutrophils against cancer
Activation of the immune system to fight cancer is a promising approach, but clinical efficacy has been limited. Current immunotherapy efforts focus mainly on T lymphocytes. The EU-funded CINPinCB project proposes neutrophils as an alternative cell therapeutic target as they are abundant in the tumour microenvironment. To investigate the complexity and heterogeneity of tumour-associated neutrophils, researchers propose to develop conditionally immortalised neutrophil progenitors as a cell source for experimental studies. The aim is to decipher the mechanisms that control the functions of these cells and generate new targets for immunotherapy.