Project description
Novel biomimetic bone implants with improved properties
Bone implants are widely used in dental and orthopedic surgeries, offering the potential to replace missing teeth or to repair joints. However, issues with long-term stability necessitate a better understanding of the interaction between the implant and the surrounding bone tissue. To address these issues, scientists of the EU-funded MIDPOINT project propose to develop biomimetic implants with mechanical properties and structure similar to those of native bone. Using computational optimisation techniques, they will design implants with improved osseointegration capacity and reduced bone resorption. MIDPOINT deliverables will assist the production of implants with optimal mechanical and functional properties.
Objective
Endosseous implants are now widely used in clinical practice to restore joint functionality or to replace missing teeth. Despite their
increasing success, implant long-term stability remains a concern and it is difficult to predict the surgical outcome so far. A
major cause of failure comes from bone resorption secondary to stress shielding, which arises from the mismatch of the
mechanical properties between the implant and the surrounding bone tissue. To overcome this problem, MIDPOINT proposes to
design porous implants that will have a biomimetic cancellous bone microstructure with a nonhomogeneous distribution of its
material properties. The optimal design will produce implants with mechanical and microstructural properties similar to that of
the bone, which will result in an improvement of the effectiveness of osseointegration phenomena.
A work methodology that combines multiscale computational modelling and experimental work for the formulation,
construction, verification and validation of computational models is proposed. This methodology will comprise i) the design of
new biomimetic microstructures that replicate the geometrical properties of the natural trabecular bone using a generative
design approach, the Voronoi tessellation approach; ii) the development of an iterative computational method to predict the
fatigue life of the artificial microstructures directly at the macroscale employing damage accumulation models coupled with
artificial neural networks; and iii) the construction of multiscale models of bone-implant systems to optimize the implant
microstructure locally in order to achieve a desirable mechanical response and functional environment for bone ingrowth
and, therefore, minimize bone resorption. These techniques will be employed to design implants and scaffolds that, together
with medical imaging techniques, can be personalized to the needs of each patient and directly printed at the medical
institution using additive manufacturing techniques.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology implants
- engineering and technology medical engineering diagnostic imaging
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.