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High-throughput and reproducible development of intestinal organoids by microfluidics encapsulation in synthetic niches for intestinal bowel disease research

Project description

The next generation of intestinal organoids for inflammatory bowel disease research

Inflammatory bowel disease (IBD) represents a spectrum of conditions that involve chronic inflammation of the digestive tract. The development of novel disease model platforms is essential for the understanding of fundamental mechanisms of the disorder. The EU-funded SYNMAT FOR ORGANOIDS project aims to develop the next generation of human intestinal organoids (HIOs) using microfluidics encapsulation in synthetic niches. This technology will enable the controlled mass production of HIOs for disease modelling, drug screening and regenerative medicine applications. The co-culturing of HIOs with immune cells and microbiota will recreate physiological conditions and provide the next generation of HIOs, which recapitulate the complex spectrum of IBD, bringing new insights into the aetiology of the disorder.

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Net EU contribution
€ 257 561,28
Address
University Road
H91 Galway
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 257 561,28

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

GEORGIA TECH RESEARCH CORPORATION
United States
Net EU contribution
€ 0,00
Address
Georgia Institute Of Technology
30332 0420 Atlanta Ga

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Activity type
Research Organisations
Other funding
€ 0,00