Project description
Proteins and receptors could form the backbone of tomorrow’s communication networks
Nature-inspired technologies for communication or signal processing are garnering global attention. The lock-and-key construct provided by the receptor-ligand interaction can impart excellent selectivity, opening the door, so to speak, only when the right key is present. These types of molecular communications substrates could subserve nano-networks of devices, where information can be exchanged between devices by the absorption or emission of specific molecules. With the support of the Marie Skłodowska-Curie Actions programme, the REINFORMATION project will characterise ligand-receptor interactions for optimisation in high data-rate and reliable molecular communications systems. Understanding will be enhanced by a novel experimental test and validation platform including proteins and receptors.
Objective
Molecular Communications (MC) is the nature’s way of networking at nanoscale, observed in almost all biological systems, including bacterial populations and nervous system. MC has been widely studied to enable the networks of artificial nanoscale devices promoting new high-impact applications such as intrabody continuous health monitoring with mobile nanosensor networks. At the core of the natural MC systems lies the ligand-receptor (LR) binding interactions, which provide the selectivity of information transfer. Likewise, LR interactions are essential for artificial MC systems to have a selective and reliable channel/receiver interface in the form of a biorecognition layer consisting of ligand receptors. Recent studies have revealed the dramatic impact of LR interactions on the overall MC performance in terms of channel bandwidth, molecular interference, receiver sensitivity and dynamic range, posing a multi-objective optimisation problem. The aim of REINFORMATION is to understand, optimise and engineer the LR interactions for high data-rate and reliable MC systems. To this end, the project will first deliver a realistic theoretical modelling and optimisation framework for MC accompanied by a microfluidic experimental test and validation platform with graphene aptasensor-based MC receivers. The framework will provide the first experimentally validated micro/nanoscale MC models, and enable the optimisation of binding affinity and kinetic rates of LR interactions from the MC perspective. The optimisation results will guide the rational design of new aptamer receptors for target information-carrying proteins, which will then be implemented on the experimental platform. The project will finally provide novel MC modulation and detection techniques, exploiting the LR interactions for high data-rate and reliable MC. Combining expertise in MC, nanotechnology, and computational biology, the project will remove a major barrier to the development of practical MC applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- engineering and technology nanotechnology nano-processes
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
34450 Istanbul
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.