Project description
Brown adipose tissue response to overfeeding in humans
Brown adipose tissue (BAT) is highly thermogenic and produces heat to maintain mammals’ body temperature. BAT’s role in adaptation to overfeeding and protecting from diet-induced obesity is well established in rodents. A decade ago, several research teams confirmed the presence of metabolically active BAT in human adults. The EU-funded BATON project develops a new method of precise measurement of human BAT volume and thermogenic capacity. The approach is based on recent advances in human BAT metabolism and will involve a randomised crossover study with 10 healthy adults. The developed method will be applied in the proof-of-concept study of BAT volume and thermogenic capacity changes in response to overfeeding.
Objective
Brown adipose tissue (BAT) is a highly thermogenic tissue whose main function is to produce heat to maintain mammals’ body temperature. In humans, it has long been believed that BAT is either absent or irrelevant in adults. However, a decade ago, several independent research groups confirmed the presence of metabolically active BAT in human adults. In rodents, BAT plays a key role in the adaptation to overfeeding, protecting murine from diet-induced obesity. Whether this phenomenon also occurs in humans is still unknown. To date, technical limitations for in vivo human BAT assessment have precluded us from adequately studying it.
The BATON study will first aim to develop a new method to accurately measure human BAT volume and thermogenic capacity in vivo. New approaches based on recent advances in human BAT metabolism (i.e. BAT’s unique ability to burn its own intracellular triglycerides and the recently discovered, and unexpected, capacity of human BAT to be activated through β2 adrenergic receptor agonism) will be tested in a randomized cross-over study. Ten young healthy adults (18-30 years old, 5 men and 5 women, with a body mass index <25kg/m2) will undergo 3 experimental sessions including sequential positron emission tomography-computerized tomography and magnetic resonance imaging and spectroscopy scans.
Later, the newly develop method(s) will be used to measure BAT volume and thermogenic capacity changes in response to a 4-week 40% overfeeding, in a proof-of-concept overfeeding pilot study. Twelve healthy adults (18-30 years old, 6 men and 6 women) with a body mass index <25kg/m2 will participate in this randomized controlled trial. After baseline assessments, participants will be randomized (blocking the randomization by sex) to a 4-week weight maintenance diet (control group) or a 40% overfeeding diet. A 5-days weight maintenance diet will be prescribed before baseline and post-intervention assessment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology mammalogy
- medical and health sciences health sciences nutrition obesity
- natural sciences physical sciences optics spectroscopy
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
18071 Granada
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.