Delivering light deep into tissue is of importance to technology in biophotonics, in particular in the context of optogenetics. One of the significant challenges is the development of bio-implantable optical probes that stimulate transgenic neurons expressing light-sensitive opsin protein (channelrhodopsin) located in deep tissues and simultaneously record eletrical, optical, or behavioral responses of neurons. Therefore, there has been a high demand for optical devices that are capable of convenient manufacturing, various form factors, and integration on a bio-implantable architecture. In addition, the mechanical robustness and some extent of flexibility of the device are important factors for bioimplants.
This project proposed a radically different device concept, a solution-phase light-emitting device (sol-LED) with a simple structure that can readily assume various forms and shapes and thus is of particular relevance to novel applications in the biomedical context. Specifically, the project addresses the following three objectives: 1) demonstration of sol-LEDs, 2) device optimization and color extension, 3) applications to stimulation of neurons in vitro and in vivo. The project has achieved most of its objectives for the period, with relatively minor deviations (details in the next section).
The MSCA project has significantly impacted the fellow’s professional career path both in scientific and non-scientific aspects. Within the project, the fellow acquired excellent experimental training and engaged in interactions with many experts. The experimental tools and resources supplied by the hosting group greatly helped the fellow create an innovative device named sol-LED and consequently become a leader of this research. In addition, the fellow was able to take a step toward biophotonics and obtained great opportunities to collaborate and discuss with people from the biological background. The outcomes achieved during the fellowship led to high-impact publications and presentations, increasing his reputation in the society of chemistry and bioengineering. In addition, the project provided a valuable opportunity for the fellow to collaborate with prominent professionals in various fields, including Prof. Kenneth Shepard on biophysics and neuroengineering at Columbia University, Prof. Karl Deisseroth on neurobiology and optogenetics at Stanford University, and Prof. Klaus Meerholz on physical chemistry and electrochemistry at Cologne University. The scientific publications, joint research, and presentations produced through the fellowship will greatly help him start a professorship in academia.
