Objective
Neurodegenerative diseases such as Alzheimers, Parkinsons or Multiple Sclerosis are severe health burdens and major global challenges for societies and healthcare systems. Therapeutic interventions in these diseases are not satisfying, since there is no treatment strategy that can halt or reverse disease progression. Several failed attempts at finding a cure for neurodegeneration have significantly reduced the interest for further research - yet, more than ever, new approaches are needed. Critically missing are pharmacologically validated targets for efficient neurodegenerative disease treatment and it is exactly here that NeuRoPROBE aims to close this gap. The orphan nuclear receptors (NR) tailless homologue (TLX) and nuclear receptor related-1 protein (Nurr1) have been identified in knockout studies as prime candidates. However, ligands for their pharmacological control as tools for therapeutic validation are lacking. NeuRoPROBE will enable pharmacological modulation of these transcription factors as a new and groundbreaking strategy to counteract neurodegeneration.
To meet its overall aim, NeuRoPROBE will (1) develop chemical probes (CP) and PROTACs for TLX and Nurr1, (2) employ generative artificial intelligence (AI) for molecular design to accelerate CP and PROTAC development, (3) establish phenotypic cellular models in 3D settings to mimic neurodegeneration, and (4) use CPs and PROTACs in the phenotypic models for pharmacological control of TLX and Nurr1 to validate their modulation in neurodegeneration.
This challenging and highly multidisciplinary endeavor will profit from my strong interdisciplinary background in the field of NR ligand discovery and pharmacology as well as in AI-based molecular design. NeuRoPROBE will open new avenues towards regenerative treatments in neurodegeneration, close the gaps in pharmacological control of TLX and Nurr1, and substantially contribute to consolidating AI techniques for structural optimization.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.