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Energy transduction in KInetically asymmetric catalytic NETworks

Objective

Endergonic processes are central to Life. They are achieved by enzymes, that change conformation during their catalytic cycle. Thus, biological non-equilibrium processes are catalysis-driven. The realization of catalysis-driven processes in artificial systems proved challenging. It remains limited to synthetically demanding interlocked structures, which were upgraded with catalytic features affecting ring sliding motion.

With KI-NET, I want to develop a general biomimetic strategy enabling endergonic processes driven by chemical catalysis. I plan to invert the current approach by introducing defined conformational freedom into simple catalytic units.
KI-NET scientific objectives go beyond state of the art in chemically-driven non-equilibrium systems, with the aim to:
(i) establish an unconventional theoretical approach based on “effective transition states”, that guides experiments and reveals common underlying principles for catalysis-driven processes and chemical oscillations;
(ii) realize endergonic conformation changes powered by catalytic processes, including ATP hydrolysis;
(iii) promote endergonic assembly reactions, that will reveal how energy consumption directs chemical adaptation;
(iv) realize an artificial synthase: a catalyst that harvests energy from one reaction and uses it to drive a different one.

I will implement a theory-guided experimental approach at the interface between systems chemistry and molecular machines. Leveraging my broad chemistry background, I will address questions that expand towards physics – in terms of formalizing models – and biology – in terms of operating systems to be imitated and unraveled.
Realizing KI-NET allows overcoming thermodynamic boundaries. Unforeseen opportunities become possible in material science and energy management, such as the realization of artificial mitochondria. Indeed, KI-NET pioneers a largely unexplored area of science at the roots of dissipative systems, complex phenomena, and –ultimately, Life.

Coordinator

CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION
Net EU contribution
€ 640 000,50
Address
Allee G Monge 8
67000 Strasbourg
France

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Region
Grand Est Alsace Bas-Rhin
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (1)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE DE STRASBOURG
France
Net EU contribution
€ 1 146 747,50
Address
Rue Blaise Pascal 4
67081 Strasbourg

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Region
Grand Est Alsace Bas-Rhin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00