Objective
There is an increasing clinical demand for sophisticated medical implants and the scientific field of implant technology is exponentially growing. The main challenge is to harness the immune response to such an implant. In this research we use the immune response to our advantage, by using bioresorbable synthetic biomaterials that are gradually replaced by living tissue inside the body. One of the key immune cells are macrophages, which are the gatekeepers for successful implant integration. Strategies to harness the macrophage response focus on isolated biomaterial design features, such as biochemical or microstructural modifications. One major neglected factor is how macrophages sense and respond to mechanical loads, such as cyclic stretch, or ‘macrophage mechanobiology’. Without an in-depth understanding of macrophage mechanobiology, rational engineering of biomaterials is not possible, leading to unpredictable outcomes and ineffective trial-and-error work.
With MACxercise, I will leverage my unique multi-disciplinary expertise in bioengineering, biomaterial science and macrophage biology to address these scientific challenges from a new angle in which macrophage mechanobiology is placed center stage. The Main Aim of the MACxercise program is to systematically dissect how macrophages respond to dynamic mechanical cues and to establish how this affects biomaterial-driven tissue regeneration. The transformative strength of MACxercise lies in the concerted spatial and temporal manipulation of the macrophage microenvironment, using sophisticated engineering tools to decouple the mechanical and physical cues to systematically pinpoint how synergistic or conflicting cues dictate key macrophage functions in the biomaterial microenvironment. With MACxercise, my vision is to catalyze the establishment of an exciting new research field across the boundaries of biomaterial science, immunology, mechanobiology, and tissue engineering.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- engineering and technology industrial biotechnology biomaterials
- medical and health sciences medical biotechnology implants
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.