Project description
Circadian rhythm and dementia
Circadian rhythm regulates essential body functions around the 24-hour day/night cycle. Patients with dementia experience disruptions in the sleep/wake cycle, suggesting that alterations of the circadian rhythm may be implicated in disease manifestation and pathogenesis. Funded by the European Research Council, the RHYTHM IN DEMENTIA project intends to employ circadian rhythm features to improve screening of patients at risk of dementia. Researchers will identify circadian rhythm features and associate them with dementia subtypes, stages and prognosis. Implementation of a circadian rhythm-based strategy for dementia screening is expected to assist in the prompt adoption of interventions to slow down progression of the disease.
Objective
Circadian rhythm (CR) regulates body functions over the 24-hour day/night period; sleep/wake cycle is its most visible manifestation. CR disruptions have long been observed in patients with dementia and emerging evidence points to their presence in the preclinical period of dementia. This suggests that certain aspects of CR could be useful in identification of high-risk individuals and could serve as potential targets for interventions to delay dementia onset and progression. This requires an in-depth understanding of the role of CR in dementia pathogenesis. As population ageing increases dementia burden, it is critical to find strategies to identify patients at risk of dementia with precision, prevent, and slow its progression. Building on recent advances in accelerometery (to assess CR features comprehensively) and dementia biomarkers (deep-phenotyping of dementia pathogenesis), RHYTHM IN DEMENTIA will make a decisive step-change in knowledge by determining CR features involved in dementia processes along the course of the disease. The aims are: 1) identify core CR features that shape 10-year risk of dementia in a community-dwelling cohort of 4000 older adults; 2) uncover specific CR disruptions that characterise major dementia subtypes and stages of Alzheimers disease (determined by biomarkers) in a new cohort of 1500 patients recruited from two memory clinics in Paris; and 3) ascertain how CR affects dementia prognosis in the patient cohort by examining cognitive and functional decline, hospitalisation, institutionalisation, and mortality.
This project will yield new insight into the nature of the association between CR and dementia progression. These findings will ultimately inform the potential for a cost-effective and easy to use tool to assess CR features to facilitate both identification of patients at risk of dementia and tailored secondary prevention interventions that address CR disruptions in dementia patients and slow progression of dementia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- social sciences sociology demography mortality
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.