Objective
Heat stress is a driver of current mass mortalities related to anthropogenic global warming. However, current approaches to study heat stress have not considered three major but little known aspects. These are (i) the ripple effect, which could amplify negative outcomes through propagating heat stress among organisms, (ii) heat stress as an evolutionary mutagen and (iii) genomic networks as filters for prezygotic selection, which together could speed up the process of evolutionary adaptation to rapidly changing environments. In this project, these properties of heat stress will be studied in vulnerable early life stages of three distinct aquatic ectotherms (a ragworm, a fish and a frog), to achieve an understanding of how universal these aspects of heat stress are among distinct, unrelated species. First this project will explore whether thermal stress can be propagated by means of chemical communication (stress metabolites) to naive receivers of different species. Outcomes on development will be compared with differential gene expression. We will then identify heat-induced stress metabolites and their molecular pathways of action, through RNAsequencing, Metabolomics and CRISPR-mediated gene editing. We will then test whether thermal stress and stress metabolites exposure induce higher mutation rates, through heat-induced transposon activity and reduced DNA repair capacity. gDNA sequencing will be combined with optical genome mapping to identify mutation rates and new structural variants. Lastly, we will identify the role of functional genomic network constraint in filtering such variants. We will sequence a reference genome, and explore through AI-led simulations whether networks with topological node constraints outperform those without constraint. Together, these objectives will transform our understanding of the mechanisms, and the extent to which organisms will respond to anthropogenic warming.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.