Translational optoelectronic control of cardiac rhythm in atrial fibrillation

Project description

Optoelectronic heart rhythm control for atrial fibrillation treatment

The EU-funded TransRhythm project aims to determine the translational potential of optoelectronic heart rhythm control for managing atrial fibrillation (AF) as the most prevalent cardiac arrhythmia. Immortalised human atrial cardiomyocytes expressing light-gated ion channels will be used to engineer human atrium-sized 3D models of AF. Multi-electrode-LED arrays will be integrated to control model optoelectronic rhythm via bioelectricity generation by precise illumination. Insights from the study will enable the application of this approach in AF animal models to determine the feasibility, safety, and therapeutic implications. The project objective is to establish principles of optoelectronic control of cardiac rhythm and discover novel insights into AF mechanisms and treatment.

Fields of science

• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › cardiac arrhythmia
• natural sciences › physical sciences › electromagnetism and electronics › optoelectronics
• medical and health sciences › medical biotechnology › genetic engineering
• medical and health sciences › medical biotechnology › tissue engineering
• natural sciences › mathematics › applied mathematics › mathematical model

Programme(s)

• HORIZON.1.1 - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2021-COG - ERC CONSOLIDATOR GRANTS

Call for proposal

ERC-2021-COG

See other projects for this call

Funding Scheme

HORIZON-AG - HORIZON Action Grant Budget-Based

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN

Net EU contribution

€ 1 999 999,00

Address

Albinusdreef 2
2333 ZA Leiden
Netherlands

Region

West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00