Objective
Nuclear pore complexes (NPCs) are fundamental components of all eukaryotic cells. They fuse the inner and outer nuclear membranes and form channels across the nuclear envelope. Their canonical function as gatekeepers of the nucleus and facilitators of nucleocytoplasmic exchange is well established. I hypothesize that NPCs fulfil yet another fundamental function as self-regulating valves for flux across the nuclear envelope that occurs in response to mechanical stress. This yet underappreciated function may be of utmost importance to prevent rupture of the nuclear envelope and thus to protect the genomic integrity in cells that are exposed to mechanical stress. I present preliminary data indicating that NPC conformation responds to mechanical force exerted onto the nuclear envelope with dilation and constriction. Cryo-electron tomography, live cell imaging, and genetic perturbation will be used jointly with structural modelling to investigate on a holistic scale how NPC diameter and nuclear envelope tension impact on flux across the nuclear envelope. In the proposed project I will demonstrate that besides their known function as transport channels the NPCs serve an important role as shock adsorbers for mechanical stress impacting the nucleus. The research proposed here will enhance our understanding of how cells deal with acute mechanical stress which is relevant for cell migration, metastasis, mechanically active tissues and cell differentiation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.