Periodic Reporting for period 1 - DESIGN OH AMR (DESIGNing the European Partnership on One Health AMR)
Reporting period: 2022-05-01 to 2024-09-30
The Coordination and Support Action (CSA) DESIGN One Health AntiMicrobial Resistance (DESIGN OH AMR) has been created in response to the HORIZON-HLTH-2021-DISEASE-04-05 call: “A roadmap towards the creation of the European partnership on One Health antimicrobial resistance (OH AMR).” Antimicrobial resistance (AMR) is recognised as major threat to the health of citizens and societies at the highest political levels, and undermines the attainment of the Sustainable Development Goals (SDGs). The WHO “Global Action Plan on AMR” and the UN Interagency Coordination Group have stressed that AMR is a global challenge requiring a global response. The G7 and G20 also endorse the need for global collaboration. The EU One Health Action Plan against AMR highlights the need for European cooperation to employ a One Health (OH) approach to tackle AMR in bacteria, fungi, viruses and parasites, which present major hazards to human, animal, plant and environmental health. DESIGN OH AMR aims to coordinate a One Health response by linking key actors of the AMR research and innovation landscape, supporting an interdisciplinary approach to overcome fragmentation. Thus, it contributes to destination 3 of the European Commission Health Programme in Horizon Europe “Tackling diseases and reducing disease burden.”
DESIGN OH AMR will lay the foundation for the future OH AMR partnership by building on the experience and outcomes of the already existing Joint Programming Initiative on Antimicrobial Resistance (JPIAMR). A core action will be the broadening of the globally recognised JPIAMR Strategic Research and Innovation Agenda (SRIA) to include a cohesive spectrum of pathogens and scientific objectives. This will be done in collaboration with key international AMR initiatives and stakeholders and synchronised with other relevant European partnerships to optimise coordination and avoid overlaps.
The major objectives of DESIGN OH AMR have been to:
1. Mobilise and link key AMR stakeholders, encompassing the human, veterinary, agricultural and environmental disciplines and including a broad spectrum of pathogens, bacteria, fungi, parasites and viruses, through a cross-cutting, interdisciplinary one health approach. The project will provide a framework to close the current knowledge gaps and break existing silos in the AMR research landscape, facilitating the integration of national and international scientific and policy communities with industry and the civic society.
2. Perform the preparatory groundwork for the candidate European partnership on OH AMR by engaging with JPIAMR members and other research funders, industry, policy makers, and already existing European partnerships and authorities to strengthen Europe’s leading role in combatting AMR through linkage with European and international initiatives such as ICARS, PENTA, EPHA and others.
3. Build the framework for the candidate OH AMR partnership by developing an updated SRIA to inform the research and innovation needs for the candidate European Partnership OHAMR, the OHAMR partnership SMART objectives, the OHAMR Roadmap of Actions, the OHAMR Work Programme for 2024-2025 and the OHAMR monitoring and evaluation framework.
4. Actively engage with and align objectives, strategies and actions with academics, innovators, end-users, researchers, public health authorities and citizens, civil societies, patients, international organisations and AMR initiatives to ensure the implementation of the European One Health AMR strategy and its contribution to the achievement of the Sustainable Development Goals.
DESIGN OH AMR will lay the foundation for the future OH AMR partnership by building on the experience and outcomes of the already existing Joint Programming Initiative on Antimicrobial Resistance (JPIAMR). A core action will be the broadening of the globally recognised JPIAMR Strategic Research and Innovation Agenda (SRIA) to include a cohesive spectrum of pathogens and scientific objectives. This will be done in collaboration with key international AMR initiatives and stakeholders and synchronised with other relevant European partnerships to optimise coordination and avoid overlaps.
The major objectives of DESIGN OH AMR have been to:
1. Mobilise and link key AMR stakeholders, encompassing the human, veterinary, agricultural and environmental disciplines and including a broad spectrum of pathogens, bacteria, fungi, parasites and viruses, through a cross-cutting, interdisciplinary one health approach. The project will provide a framework to close the current knowledge gaps and break existing silos in the AMR research landscape, facilitating the integration of national and international scientific and policy communities with industry and the civic society.
2. Perform the preparatory groundwork for the candidate European partnership on OH AMR by engaging with JPIAMR members and other research funders, industry, policy makers, and already existing European partnerships and authorities to strengthen Europe’s leading role in combatting AMR through linkage with European and international initiatives such as ICARS, PENTA, EPHA and others.
3. Build the framework for the candidate OH AMR partnership by developing an updated SRIA to inform the research and innovation needs for the candidate European Partnership OHAMR, the OHAMR partnership SMART objectives, the OHAMR Roadmap of Actions, the OHAMR Work Programme for 2024-2025 and the OHAMR monitoring and evaluation framework.
4. Actively engage with and align objectives, strategies and actions with academics, innovators, end-users, researchers, public health authorities and citizens, civil societies, patients, international organisations and AMR initiatives to ensure the implementation of the European One Health AMR strategy and its contribution to the achievement of the Sustainable Development Goals.
The activities in CSA DESIGN OH AMR have been done in the framework of 4 work packages, each with their own objectives.
Work package 1 has focused on delivering efficient coordination and management of the project, including support to all partners, follow up of deliverables and timelines, and ensuring the relevance of the overall direction of the emerging partnership proposal. This WP has delivered several core aspects of the partnership structure; the intervention logic, a monitoring and evaluation framework, the governance structure, and the proposal itself.
Work package 2 was dedicated to the preparation of the Strategic Research and Innovation Agenda (SRIA), including a Roadmap for implementation and a Work Programme for the first year of the partnership. These core strategic documents were prepared with broad engagement of the AMR community across sectors and research fields, and successfully delivered. The scientific and methodological priorities are aligned with global and EU strategies, ensuring that the partnership will create value for citizens, professionals, and society in Europe and beyond.
Work package 3 strengthened the foundation for the OHAMR partnership in terms of exploring and developing synergies and opportunities for collaboration with key AMR stakeholders in Europe and globally, representing all aspects of AMR efforts across society. The result is a partnership consortium with representation from national and regional research funders, national governments, expertise in drug development, diagnostics, interventions, capacity strengthening, research data management, and policy engagement. The consortium has also established contacts with relevant EU and UN agencies.
Work package 4 has supported the activities and deliveries of the other WPs by providing a dissemination, exploitation, and communication strategy as well as tools and activities to increase the visibility of the partnership preparations, attract engagement for SRIA consultations, and aid the development of synergies with other stakeholders.
The outcomes of the action are the updated Strategic Research and Innovation Agenda and the finalised proposal for the European Partnership One Health AntiMicrobial Resistance.
Work package 1 has focused on delivering efficient coordination and management of the project, including support to all partners, follow up of deliverables and timelines, and ensuring the relevance of the overall direction of the emerging partnership proposal. This WP has delivered several core aspects of the partnership structure; the intervention logic, a monitoring and evaluation framework, the governance structure, and the proposal itself.
Work package 2 was dedicated to the preparation of the Strategic Research and Innovation Agenda (SRIA), including a Roadmap for implementation and a Work Programme for the first year of the partnership. These core strategic documents were prepared with broad engagement of the AMR community across sectors and research fields, and successfully delivered. The scientific and methodological priorities are aligned with global and EU strategies, ensuring that the partnership will create value for citizens, professionals, and society in Europe and beyond.
Work package 3 strengthened the foundation for the OHAMR partnership in terms of exploring and developing synergies and opportunities for collaboration with key AMR stakeholders in Europe and globally, representing all aspects of AMR efforts across society. The result is a partnership consortium with representation from national and regional research funders, national governments, expertise in drug development, diagnostics, interventions, capacity strengthening, research data management, and policy engagement. The consortium has also established contacts with relevant EU and UN agencies.
Work package 4 has supported the activities and deliveries of the other WPs by providing a dissemination, exploitation, and communication strategy as well as tools and activities to increase the visibility of the partnership preparations, attract engagement for SRIA consultations, and aid the development of synergies with other stakeholders.
The outcomes of the action are the updated Strategic Research and Innovation Agenda and the finalised proposal for the European Partnership One Health AntiMicrobial Resistance.
The results of the CSA DESIGN OH AMR are the partnership consortium and the partnership proposal, which has been reviewed and invited to start Grant Agreement Preparations.
The potential impact of the consortium, which has expanded from current JPIAMR members to also include organisations that bring technical or systems expertise in AMR specific and AMR sensitive areas, is the partnership's readiness to engage stakeholders across the AMR ecosystem, to ensure relevance of the new knowledge generated and support the uptake of results among industries, end-users, and policy-makers. The potential impact of the partnership proposal is the boosting of AMR research and innovation while also strengthening capacity, sustainability, and resource management in AMR efforts.
Taken together, the partnership consortium and its ambitious work programme will break current silos in AMR efforts globally and contribute to fulfilling EU and global AMR strategies (see the attached Partnership Specific Impact Pathway for the interconnectedness of operations, outcomes, impact and macro-level objectives).
The potential impact of the consortium, which has expanded from current JPIAMR members to also include organisations that bring technical or systems expertise in AMR specific and AMR sensitive areas, is the partnership's readiness to engage stakeholders across the AMR ecosystem, to ensure relevance of the new knowledge generated and support the uptake of results among industries, end-users, and policy-makers. The potential impact of the partnership proposal is the boosting of AMR research and innovation while also strengthening capacity, sustainability, and resource management in AMR efforts.
Taken together, the partnership consortium and its ambitious work programme will break current silos in AMR efforts globally and contribute to fulfilling EU and global AMR strategies (see the attached Partnership Specific Impact Pathway for the interconnectedness of operations, outcomes, impact and macro-level objectives).