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Reducing the impact of major environmental challenges on mental health

Objective

The environMENTAL project will investigate how some of the greatest global environmental challenges, climate change, urbanisation, and psychosocial stress caused by the COVID-19-pandemic affect mental health over the lifespan. It will identify their underlying molecular mechanisms and develop preventions and early interventions. Leveraging cohort data of over 1.5 million European citizens and patients enriched with deep phenotyping data from large scale behavioural neuroimaging cohorts, we will identify brain mechanisms related to environmental adversity underlying symptoms of depression, anxiety, stress and substance abuse. By linking population and patient data via geo-location to spatiotemporal environmental data derived from remote sensing satellites, climate models, regional-socioeconomic data and digital health applications, our interdisciplinary team will develop a neurocognitive model of multimodal environmental signatures related to transdiagnostic symptom groups that are characterised by shared brain mechanisms. We will uncover the molecular basis underlying these mechanisms using multi-modal -omics analyses, brain organoids and virtual brain simulations, thus providing an integrated perspective for each individual across the lifespan and spectrum of functioning. The insight gained will be applied to developing risk biomarkers and stratification markers. We will then screen for pharmacological compounds targeting the molecular mechanisms discovered. We will also reduce symptom development and progression using virtual reality interventions based on the adverse environmental features - developed in close collaboration with stakeholders. Overall, this project will lead to objective biomarkers and evidence-based pharmacologic and VR-based interventions that will significantly prevent and improve outcomes of environmentally-related mental illnesses, and empower EU citizens to manage better their mental health and well-being.

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Net EU contribution
€ 1 983 500,00
Address
Chariteplatz 1
10117 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 983 500,00

Participants (17)

FREIE UNIVERSITAET BERLIN
Germany
Net EU contribution
€ 192 000,00
Address
Kaiserswerther Strasse 16-18
14195 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 192 000,00
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
Net EU contribution
€ 641 500,00
Address
Square J 5
68159 Mannheim

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Region
Baden-Württemberg Karlsruhe Mannheim, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 641 500,00
UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN
Germany
Net EU contribution
€ 721 350,00
Address
Ratzeburger Allee 160
23562 Lübeck

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 721 350,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
Net EU contribution
€ 0,00
Address
Olshausenstrasse 40
24118 Kiel

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Region
Schleswig-Holstein Schleswig-Holstein Kiel, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITETET I OSLO
Norway
Net EU contribution
€ 733 625,00
Address
Problemveien 5-7
0313 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Other funding
€ 733 625,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

OSLO UNIVERSITETSSYKEHUS HF
Norway
Net EU contribution
€ 0,00
Address
Kirkeveien 166 Tarnbygget
0450 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAET POTSDAM
Germany
Net EU contribution
€ 147 000,00
Address
Am Neuen Palais 10
14469 Potsdam

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Region
Brandenburg Brandenburg Potsdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 147 000,00
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 476 500,00
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 476 500,00
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria
Net EU contribution
€ 430 000,00
Address
Am Campus 1
3400 Klosterneuburg

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Region
Niederösterreich Wiener Umland/Nordteil
Activity type
Higher or Secondary Education Establishments
Other funding
€ 430 000,00
UNIVERSITAT DE BARCELONA
Spain
Net EU contribution
€ 587 188,00
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Other funding
€ 587 188,00
UNIVERSITATSKLINIKUM BONN
Germany
Net EU contribution
€ 195 000,00
Address
Venusberg-campus 1
53127 Bonn

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Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 195 000,00
LIFE AND BRAIN GMBH
Germany
Net EU contribution
€ 1 252 500,00
Address
Venusberg-campus 1
53127 Bonn

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 252 500,00
KSILINK
France
Net EU contribution
€ 710 000,00
Address
16 Rue D'ankara
67000 Strasbourg

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Region
Grand Est Alsace Bas-Rhin
Activity type
Research Organisations
Other funding
€ 710 000,00
UNIVERSITE D'AIX MARSEILLE
France
Net EU contribution
€ 197 000,00
Address
Boulevard Charles Livon 58 Le Pharo
13284 Marseille

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Region
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône
Activity type
Higher or Secondary Education Establishments
Other funding
€ 197 000,00
VIRTUAL BODYWORKS SL
Spain
Net EU contribution
€ 195 625,00
Address
Carrer De Llanca Num. 51 P.12 Pta.2
08015 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 195 625,00
ARTTIC INNOVATION GMBH
Germany
Net EU contribution
€ 390 500,00
Address
Oskar-von-miller-ring 29
80333 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 390 500,00
FRIEDRICH-SCHILLER-UNIVERSITAT JENA
Germany
Net EU contribution
€ 192 000,00
Address
Furstengraben 1
07743 Jena

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 192 000,00

Partners (6)

FUDAN UNIVERSITY
China
Net EU contribution
€ 0,00
Address
Handan Road 220
200433 Shanghai

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC
United States
Net EU contribution
€ 0,00
Address
58 Edgewood Avenue 3rd Floor
30303 Atlanta

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Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITY OF SOUTHERN CALIFORNIA
United States
Net EU contribution
€ 0,00
Address
3551 Trousdale Pkwy Adm 352
90089 5013 Los Angeles Ca

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Google LLC
United States
Net EU contribution
€ 0,00
Address
1600 Amphitheatre Pkwy
94043 Mountain View

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 0,00
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
No data
DE MONTFORT UNIVERSITY
United Kingdom
Net EU contribution
€ 0,00
Address
The Gateway
LE1 9BH Leicester

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Region
East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester
Activity type
Higher or Secondary Education Establishments
Other funding
No data