Project description
A supreme weapon against antibiotic resistance
Multi-drug resistant (MDR) bacteria emerge from the accumulation of multiple genes conferring resistance to different antibiotics. These microorganisms pose a serious medical challenge, threatening the outcome of simple surgeries and infections. Funded by the Marie Skłodowska-Curie Actions programme, the SUPREME project aims to develop an innovative therapeutic approach against MDR bacteria using nitric oxide (NO). NO is implicated in immune reactions against various pathogens and also inhibits drug efflux pumps responsible for multi-drug resistance. Researchers will develop a sophisticated nanosystem that responds to light to release the therapeutic cargo such as antibiotics and NO.
Objective
With more than 13 million people dying per year from infectious diseases Multidrug Resistance (MDR) in bacteria remains the
greatest challenge in public health care. This scenario, associated to the low turnover of new clinically approved antibiotic
drugs makes the development of innovative therapeutic approaches to fight antibiotic resistance desperately needed to
address this devastating societal problem. In this frame, SUPREME aims at the implementation of a novel strategy based
on unprecedented supramolecular platforms based on new cyclodextrin polymers integrating light-activatable nitric oxide (NO)
photodonors (NOPD), alone and in combination with antibiotics currently employed in the clinic. The final goal is to exploit
the double role of NO generated with superb spatiotemporal control thanks to the light triggering, as: i)
bactericidal species not suffering MDR when produced at high doses (micro molar); ii) inhibitor of the efflux pumps mainly responsible
for MDR, when produced at low doses, to revert antibiotic resistance. Highly biocompatible branched polymers containing mixed (alpha, beta and gamma) cyclodextrin units will be used as suitable hosts able to self-assemble into nanoparticles or gels
encapsulating the therapeutic cargo with high efficiency. We will focus on NOPDs activatable exclusively with the
biocompatible visible light and on antibiotics representative of the classes of fluoroquinolones and
tetracyclines, known to display resistance and severe side effects. Full chemico-physical and photochemical characterization
of the systems is planned as well as assessment of their efficacy against planktonic microbial cells and biofilms. The complementary
expertise of the researcher and the supervisor supported by the private and academic teams hosting the fellow during
secondments will create a multidisciplinary environment where all participants will benefit from reciprocal transfer of
knowledge.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences chemical sciences polymer sciences
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- engineering and technology nanotechnology nano-materials
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
95131 CATANIA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.