Objective
"Developing new pharmaceutically-active molecules for the treatment of diseases that compromise the health and well-being of society is an essential but tedious process with rising costs, partially due to the arduous chemical synthesis of complex drug candidates. Recently, innovations in organic chemistry have streamlined the access to vast libraries of drugs by applying novel methodologies such as Late-Stage Functionalization of C-H bonds. However, one of the major challenges of editing biologically-active chemical structures is the development of processes that are compatible with diverse functional groups and functionalize one single position ""à la carte"" in an efficient and predictable manner.
SELECTFLOW presents a multidisciplinary project that lies in the intersection of synthetic photoredox catalysis with microfluidic technologies, with the objective of delivering a selective, sustainable and predictable methodology for the modification of biologically-active molecules using light alkanes as raw materials. This will require the accomplishment of three specific objectives:
1) Development of a chemo- and regioselective synthetic methodology for the edition of nitrogen-containing aromatic heterocycles.
2) Translation of the developed photocatalytic system into a microflow-based setup, to enable the use of gaseous reagents in a milder and scalable fashion.
3) Understanding the mechanistic intricacies of the developed methodology in order to predict unexplored similar transformations.
Overall, this proposal directly tackles one of the most important challenges for the pharmaceutical industry, the rapid and cost-effective production of innovative drugs, by delivering a sustainable valorisation of greenhouse gases, such as methane. It is expected that this innovative approach will be of high scientific, technological and societal impact, ultimately reinforcing the already European competitiveness in the production of life-saving drugs."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences organic chemistry aliphatic compounds
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1012WX Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.