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Development of personalized and affordable multi-substituted calcium phosphate based scaffolds for bone augmentation applications

Project description

Preparing the next-generation bone augmentation procedures

Healthcare, in general, and orthopaedics and bone treatments, more specifically, are a few of the crucial fields that 3D printing has revolutionised. Trying to answer the demand for more affordable and personalised treatments for osteopathic patients, the EU-funded AffordBoneS aims to explore the field of bone regeneration and offer customised and low-cost solutions for bone augmentation. The project brings together a series of diverse experts from the fields of material engineering, biology, medicine and pharmaceutics to develop scaffolds obtained by using 3D-printable calcium phosphate multi-substituted with ions.

Objective

Less than half of the global population is covered by essential healthcare services and the aim of the postdoctoral fellowship project AffordBoneS is to obtain personalized and affordable scaffolds for bone augmentation procedures. Dr. Antonia Ressler (applicant) will study scaffolds obtained by using 3D-printable calcium phosphate multi-substituted with ions (strontium, magnesium, and zinc) crucial for efficient bone regeneration. Stereolithography, as an additive manufacturing technique, is going to be used for printing precise, highly porous, scaffolds based on multi-substituted calcium phosphates for bone augmentation procedures in collaboration with the company Lithoz. After the detailed analysis of physicochemical properties of printed scaffolds, in vitro and in vivo biological properties will be obtained to determine the scaffold's osteogenic properties and the influence of substituted ions on bone regeneration by using stem cells from female and male donors and female and male rats, respectively. Further, company Planmeca will provide patient real cases and the needed technologies for obtaining a demonstration of a personalized scaffold, customized to the patient complex jaw bone defect. The project will be carried out at the Faculty of Engineering and Natural Sciences and the Faculty of Medicine and Health Technology of Tampere University, under the supervision of Prof. Erkki Levanen and co-supervision of Prof. Susanna Miettinen. AffordBoneS project requires a high level of interdisciplinary work and the project is planned bearing in the mind that the improvement in the field of bone regeneration relies on bringing together experts from different fields, who are nowadays distant from each other, such as material engineers, biologists, clinicians, surgeons, and related companies.

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Coordinator

TAMPEREEN KORKEAKOULUSAATIO SR
Net EU contribution
€ 215 534,40
Address
Kalevantie 4
33100 Tampere
Finland

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Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Higher or Secondary Education Establishments
Links
EU contribution
No data