Project description
The determinants of organism size
Undoubtedly there’s a correlation between organ and organism size and energy requirements. However, is energy the only parameter that determines organ and organism size? Funded by the Marie Skłodowska-Curie Actions (MSCA) programme, the SizeGrowth project aims to address this question by studying the dynamic process of growth in Drosophila melanogaster. Researchers will correlate organism growth with energy fluctuations and unveil the mechanisms of growth arrest during development. Results will also answer whether in the fruit fly larvae the cellular metabolic power decreases with increasing organism mass as stated by Kleiber’s law.
Objective
What determines organ and organism size is a fundamental question that remains unanswered. All through development, organ size increases while being scaled to organism size, until growth terminates. This project addresses the question of how growth is regulated and arrests during development. We propose that energy becomes limiting throughout development and thus sets final size. Indeed, Kleiber's law postulates that the cellular metabolic power decreases with increasing organism mass, limiting the energy assigned for growth. Using Drosphila melanogaster as a model organism, we aim to study growth directly as a 3D dynamic process in order to address the question of how organs and organisms form with consistent size and shape. We will track organism growth in terms of mass and volume as well as organ growth during the larval period of development. By correlating size increase to energy fluctuations, we will uncover to what extent fly larvae follow Kleibers law and whether individual organs also follow the same rule. Finally, we will consider three pillars that restrict growth capacity of organs by constraining energy: fractal transportation (branching), morphogenetic gradients and mechanics, and demonstrate how growth arrests during development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.