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Nanoagent-based three-method treatment for atherosclerosis: Combination of thermal, mechanical, and drug-based methods

Description du projet

Un traitement combiné de l’athérosclérose fondé sur les nanostructures

L’athérosclérose (AS) est une maladie associée à l’accumulation de plaques de cholestérol sur la paroi interne des artères, qui se durcissent et se rétrécissent, et peut provoquer une crise cardiaque ou un accident vasculaire cérébral. L’objectif du projet NanoTAS, financé par le programme Actions Marie Skłodowska-Curie, est de développer un nouveau traitement combiné de l’AS qui utilise des agents nanostructurés. Cette approche combine des traitements thermiques et mécaniques et la libération ciblée de médicaments anti-AS. Les chercheurs veulent réduire l’inflammation des vaisseaux sanguins, casser les plaques athéroscléreuses existantes et permettre l’administration de médicaments spécifiques. La stratégie de NanoTAS devrait produire un résultat optimal pour les patients atteints d’AS.

Objectif

The aim of NanoTAS is to propose a novel three-method treatment for the atherosclerosis (AS) disease based on nano-structured agents (NAs), which incorporates three kinds of methods into a single one: 1) Thermal treatment, 2) Mechanical treatment, and 3) Anti-AS drug-based treatment. The NAs employed in the NanoTAS are proposed to have a novel composite structure including magnetic agents (ferrite-based nanorods; FNRs) and plasmonic agents (Au nanostars; AuNSs). Thermal treatment is accomplished through magneto-photo thermal therapy (MPTT), a combination of magnetic hyperthermia therapy (MHT) using FNRs under alternating magnetic field (AMF) and photothermal therapy (PTT) using AuNSs under near-infrared laser (NIR-laser) while mechanical treatment is performed through rotation of NAs (by their magnetic part i.e. FNRs) under rotating magnetic field (RMF). The NAs also load anti-AS drug and deliver it to target sites through a biocompatible and thermo-sensitive polymer. Accordingly, the specific objectives of NanoTAS can be summarized as: Oi) Decreasing the inflammation in blood vessels involved in the AS through thermal treatment (MPTT). Oii) Targeted release of anti-AS drug using a thermo-sensitive mechanism triggered by thermal treatment. Oiii) Breaking and abrading plaques using mechanical treatment through rotation of NAs under RMF. The objectives are achieved through applying the external stimuli on the drug-loaded NAs, during the following steps: Step 1) Applying both AMF and NIR-laser: This is a two-purpose step in which thermal treatment is accomplished aiming both decrease in inflammation (Oi) and drug release (Oii). Step 2) Applying RMF: This step is applied for breaking and chipping the structure of plaques (Oiii). Step 3) Repeating the step 1: This step is a supplementary one to decrease in remaining inflammation (Oi).

Régime de financement

MSCA-PF - MSCA-PF
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Coordinateur

UNIVERSIDAD DE GRANADA
Contribution nette de l'UE
€ 165 312,96
Adresse
Cuesta del hospicio sn
18071 Granada
Espagne

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Région
Sur Andalucía Granada
Type d’activité
Higher or Secondary Education Establishments
Liens
Contribution de l’UE
Aucune donnée