Objective
Viral infections are a major threat to public health worldwide. The innate immune response acts as the first line of defense during viral infections by recognizing pathogen-associated molecular patterns such as double-stranded RNA (dsRNA). Impaired innate immune signaling sensitizes patients to viral infections, while aberrant innate immune activation is associated with autoimmune diseases.
Recently, the host laboratory identified the protein kinase TAOK2 as a novel co-factor for viral dsRNA sensing. TAOK2 binds and is activated by dsRNA, and its depletion leads to an impaired immune response to viral infection. Notably, a mutation in TAOK2 causes immunodeficiency in human patients. These findings suggest a previously unappreciated role for TAOK2 in innate immunity, but the molecular details remain unclear.
I will use synergistic biochemical, systems biology and in vivo approaches to comprehensively define the role of TAOK2 in innate immunity. First, I will use state-of-the-art biochemical and structural approaches to define the mechanism of dsRNA recognition by TAOK2 and discern the molecular basis for the disease-causing point mutation. Second, I will perform a multi-level systems biology analysis to integrate TAOK2 into a dynamic signaling network in response to viral infection. Third, I will assess the consequences of complete loss of TAOK2 and the clinically relevant TAOK2 point mutation in vivo using mouse models.
This highly interdisciplinary and collaborative project will combine my existing expertise in biochemistry and in vivo approaches with the systems biology competencies of the host laboratory. Thereby, I will gain novel insight into the signaling network that governs the innate immune responses to viral dsRNA. The training during this project will increase my scientific and transferable skills, reintegrate me into the European research community, and thereby help me achieve professional maturity and academic independence.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry
- natural sciences biological sciences microbiology virology viromes
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80333 Muenchen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.