Project description
Further insights into the neurobiological underpinnings of ADHD
Attention deficit hyperactivity disorder (ADHD) is a condition that affects one’s behaviour, from having a short attention span to being constantly in motion, amongst other symptoms. As one of the most common neurodevelopmental disorders, it affects both children and adults. The Marie Skłodowska-Curie Actions (MSCA) NeuroADHD project will investigate the neurobiological mechanisms underlying the developmental course of ADHD within a longitudinal sample. To do this, the project will examine the anatomical scans of 1 069 children, made up of those with and without ADHD, among other key actions. Project work will lead to an enhanced overall picture on the developmental trajectories of ADHD.
Objective
Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, with 5% of children and 2.5% of adults being affected. Core symptoms include inattention, hyperactivity, impulsivity, and cognitive dysfunctions, causing a significant burden in multiple domains of daily life. Delayed brain maturation in childhood and adolescence is suggested as neurobiological underpinning of ADHD, but longitudinal studies are scarce and have partly revealed divergent results. The aim of the present project is to investigate the neurobiological mechanisms underlying the developmental course of ADHD within an independent, closely monitored, and well-characterized longitudinal sample (Dutch NeuroIMAGE cohort). Brain anatomical scans of initially 1,069 children (with and without ADHD) will be analysed with regard to the development of cortical thickness, surface area, and subcortical volumes, from childhood over adolescence into adulthood. An additional ultra-high field (7 Tesla) brain scan acquired in young adulthood will be used to precisely investigate cortical myeloarchitecture. All measures will be analysed with respect to clinical outcomes, that is, comparing patients with persistent ADHD, patients with ADHD in childhood who have remitted into adolescence or adulthood, and healthy controls. To further understand what mediates or moderates individual differences in ADHD-associated brain maturation, the role of genetic and environmental risk factors will be considered. This project is expected to lead to an enhanced overall picture on the developmental trajectories of ADHD. Identification of interindividual differences between individuals with persistent ADHD and those who recover as well as influencing factors will not only provide further insights into the neurobiological underpinnings of ADHD, but could also have high value for individualization and optimization of treatment approaches.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6525 GA NIJMEGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.