Skip to main content

Decoding Gut microbiota-modulation of Memory

Objective

Our memory is essential for all aspects of our lives. Memories are encoded in the brain by coordinated neuronal activity in the hippocampus. Disruption of this coordination is associated with neurological/psychiatric disorders such as Alzheimer’s disease and schizophrenia affecting spatial and social memories. Emerging data suggests that the gut microbiota can influence the brain through the vagus nerve with involvements in an increasing number of mental health conditions including those impairing memory. However, these associations are correlative and the precise microbiota-vagal effects on brain physiology remain to be defined. Can we decode hippocampal neuronal mechanisms contributing to gut-vagal modulation of memory? REMEMBER aims to establish an integrative functional definition of two distinct and specialised neuronal pathways arising from the vagus-innervated brainstem which are likely to carry microbiota-initiated information into the hippocampus. By combining state-of-the-art viral tracing, behavioural tests, microbiome-vagal manipulations and in vivo electrophysiology, I propose investigations of progressive levels of biological complexity. REMEMBER will bring new insights into the regulation of memory and may pave the way for transformative microbiota- and vagus-oriented treatments for people living with memory decline, addressing a public health priority. I will design an open sharing strategy for the dissemination and communication of my findings to maximise their impact. This fellowship will provide me with interdisciplinary expertise by complementing my knowledge in neuroscience with microbiome research and it will support my transition to independence at APC Microbiome Ireland. I will grow my network and gain valuable international training and intersectoral exposure through secondments at Icahn School of Medicine in New York and The Allen Institute for Brain Science in Seattle strengthening my competitiveness for independent group leader positions.

Coordinator

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Net EU contribution
€ 215 534,40
Address
Western Road
T12 YN60 Cork
Ireland

See on map

Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Partners (2)

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States
Net EU contribution
€ 0,00
Address
One Gustave L Levy Place Box 1075
10029 6574 New York

See on map

Activity type
Higher or Secondary Education Establishments
Other funding
No data
ALLEN INSTITUTE
United States
Net EU contribution
€ 0,00
Address
615 Westlake Ave N
98109 Seattle Wa

See on map

Activity type
Research Organisations
Other funding
No data