Objective
Osteoarthritis (OA) is a disease that gradually degrades the cartilage joints, affecting more than 50 million people in Europe. With no known treatment, this population is at risk of lower quality of life and permanent disability. The chondrocyte is a native cell in the cartilage joints that has been studied as a promising cell therapy agent for early-stage OA. Recently, by using a stimuli-responsive (SR) culture plate, many cell types can be prepared as a sheet-like cluster (cell sheet) analogous to the native biological tissue, entailing the enhanced regenerative efficacy when used as cell therapy. However, it is challenging to prepare the chondrocyte cell sheet, as the chondrocyte gradually loses the cartilage feature upon being cultured on the stiff SR plate. In this project, I aim to prepare the cartilage-like chondrocyte cell sheet by developing an innovative technique that is premised on the tuning of substrate stiffness during the cell culture stage. I will focus on three objectives: (1) to develop a new cell sheet-fabrication substrate that has the magnetically tunable stiffness, (2) to study the proof-of-concept of the tunable stiffness technique for modifying the model cell sheet activities, and (3) to apply this dynamic technique to obtain the cartilage-like chondrocyte cell sheet of which its regenerative efficacy against early-stage OA will be evaluated. To perform this project, I will draw from and extend upon my current expertise and works in biomaterial development and stiffness-cell interaction, with that of academic host Prof. Berensmeier (magnetic nanotechnology) and of industrial partner Dr. Vonk (cartilage cell therapy). This synergized academic-industry partnership will continue to the non-academic placement, wherein I will undertake the next-stage preclinical developments of chondrocyte cell sheets in a deeper and more relevant context of OA treatment. The proposed project gives a great contribution to the OA-stricken European society.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80333 Muenchen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.