Objective
Enhancing plants natural innate and immune systems for the generation of primed plants that will better withstand stressors, can be an effective way to reduce losses in crop production. These systems are broadly defined under the plant transgenerational inheritance (TI) of stress memory, which is based on the heritability of attained traits caused by environmental conditions. I propose a new player in plant TI: the extrachromosomal circular DNA (eccDNA). EccDNA is recognized as a major source of genetic variation behind key adaptive traits. I hypothesize that stress-responsive eccDNAs in the soma of a plant can be considered as adaptive toolkits, that can be transferred to the gametes during meiosis, and thus to the progeny. Thus, I have developed an ambitious but feasible plan, to bridge two major gaps in this context: (1) We require innovative technologies to prove causation, so I will develop the first and novel genetic toolbox to study eccDNAs in plants, by targeted circularization driven by the novel CRISPR-C system; (2) We lack knowledge about how eccDNAs are inherited, so I will characterize the transmission of eccDNAs from the soma to the gametophyte in Arabidopsis, through genome-scale (Circle-seq) and cytological analysis (FISH). CirclePLANT offers a unique opportunity for the development of a new line of research, with potentially remarkable impact because it will explore the bases for eccDNA-based technologies that may be useful in crop breeding, ultimately leading to the generation of stable climate-smart crops, which fits with the environmental objectives of the European Common Agricultural Policy (CAP) of improving crop yields by applying low-input agricultural practices.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences genetics heredity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.