Objective Abuse and overuse of antibiotics has led to antimicrobial resistance (AMR), which is a major global health concern. In the EU, there are around 30,000 AMR-related deaths per year, and the incidence of AMR is on the rise; experts have predicted a loss of 10 million lives by 2050. One of the reasons to find alternatives to tackle this grave and complicated health challenge is that only very few antibiotics are discovered and those in the pipeline do not have the ability to circumvent AMR development in microbes. Thus, there is a need for discovery of novel antimicrobial agents that can take the place of conventional antibiotics. In comparison to conventional antibiotics, antimicrobial peptides (AMPs) especially bacteriocins, are effective in rapidly eradicating microbes, thereby reducing AMR-related issues. Hence, the proposed project aims to identify ideal AMPs that can eradicate pathogens and reduce the emergence of AMR. The approach will be to mine the sequences of the most dominant commensal genomes to identify suitable candidate AMPs. The identified AMPs will be stored in an online catalogue which can be leveraged by researchers working in the same field. Furthermore, the anti-pathogenic ability of the selected AMPs will be confirmed through in-vitro techniques followed by studying their AMR developing propensity. Additionally, genes leading to AMR will be identified and knocked out to study the effect on AMR. Furthermore, the synergistic activity of the identified AMPs along with antibiotics will also be studied. These objectives will be achieved by using advanced computational and machine learning techniques followed by in-vitro techniques. The project will lead to discovery of AMPs with least AMR developing propensity and will also provide information about putative AMPs that can be developed along with Toscana Life Sciences (TLS) Foundation (industrial placement) to explore their therapeutic potential. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencescomputer and information sciencesartificial intelligencemachine learningnatural sciencesbiological sciencesmicrobiologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Keywords Antimicrobial peptides antimicrobial resistance human microbiome antibiotics sequence analysis genome data mining Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2021-PF-01-01 - MSCA Postdoctoral Fellowships 2021 Call for proposal HORIZON-MSCA-2021-PF-01 See other projects for this call Funding Scheme HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships Coordinator NORD UNIVERSITET Net EU contribution € 283 438,80 Address UNIVERSITETSALLEEN 11 8026 Bodo Norway See on map Region Norge Nord-Norge Nordland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partners (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all FONDAZIONE EDMUND MACH Italy Net EU contribution € 0,00 Address VIA EDMONDO MACH 1 38098 San Michele All'Adige See on map Region Nord-Est Provincia Autonoma di Trento Trento Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Toscana Life Sciences Sviluppo Italy Net EU contribution € 0,00 Address Via Fiorentina 1, Siena (Italy) 53100 Siena See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
