Objective
The ability to form emotional memories of aversive or rewarding stimuli is a crucial ability to determine avoidance or approaching behavior. Recent reports identify specific populations of nThe ability to form emotional memories of aversive or rewarding stimuli is a crucial ability to determine avoidance or approaching behavior. Recent reports identify specific populations of neurons within the basal and lateral nucleus of the amygdala (BLA) and their corresponding projections that are selectively activated during the retrieval of memories of positive or negative valence. Interestingly, BLA neurons projecting to the CA1 area of ventral hippocampus (vCA1) are tuned for either positive or negative predicting cues, suggesting the existence of two distinct pathways routing opposite information to vCA1. How emotional values originating from the BLA are differentially processed by downstream vCA1 neurons remains unclear. An appealing possibility is that vCA1 encodes different valence-related information through distinct spiking patterns and temporal structures. Distinct signal processing in the two BLA-vCA1 pathways might be supported by specific non-linear dendritic input integration, a mechanism that can be promoted by input clustering induced by heterosynaptic plasticity. We hypothesized that an organized synaptic distribution within BLA-vCA1 subnetworks exists, and that local heterosynaptic plasticity determines different temporal structures of neuronal output vCA1 in the processing of negative or positive information. We will use a novel viral-based tracing approach combined with an established assembly-labeling strategy to understand the anatomical input-specific structural organization synapses of different valence-related information along vCA1 dendritic arbour. Then, to dissect the functional implication of such synaptic organization, we will employ a combination of single-spine calcium imaging, electrophysiology, behaviour and in vivo endoscopic calcium imaging.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences computer and information sciences data science data processing
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
16163 GENOVA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.