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Distributed and federated cross-modality actuation through advanced nanomaterials and neuromorphic learning

Objective

A vast number of pathological brain conditions directly involve aberrant electrical activity of the brain. CROSSBRAIN centres its technological revolution on the convergence of novel nanoactuation modalities, bleeding-edge nano-electronics, and miniaturized wireless energy harvesting and communication. Combining extreme edge computing with advanced nanomaterials featuring tailored physical properties, biocompatible coatings, and material modifications to prevent glial scarring, CROSSBRAIN will enable individualized, adaptive and highly spatiotemporally localized actuation of brain tissue. It will leverage sensing electric local field potentials, multiunit neuronal activity, and cross-modal nanomaterial-based modulation (electrical, mechanical, thermal, ionic concentration, optogenetics) of neuronal excitability with on-board intelligence. The CROSSBRAIN platform comprises a swarm of wireless, implantable, MRI-compatible microbots for in vivo electrophysiology and cross-modal neuromodulation at the cell- and microcircuit levels, in freely moving rodents. CROSSBRAIN delivers a multiplicity of stimulation modalities, involving electro-mechano-magneto-thermo-optical principles for modulation of nerve cell excitability. The microbots will feature both sensing and actuation electrodes, engineered with nanomaterials and viral vectors coatings. They will be implanted endovascularly, deliver genetic material upon command, and operate in federation under the networked control and wireless power supply by a tiny central unit, which can be worn like an internet of things device. CROSSBRAIN will deliver autonomous or manual, closed-loop sensing, prediction, and actuation through combining multiple neuromodulation mechanisms, which will act in a synergistic and dynamic manner to optimally shape stimulation according to individual neuronal firing patterns or clinician’s needs. As case studies, we will explore CROSSBRAIN action in animal models of Parkinson’s Disease and Epilepsy.

Coordinator

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Net EU contribution
€ 696 058,75
Address
Via Cracovia 50
00133 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Other funding
€ 696 058,75

Participants (7)

SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
Italy
Net EU contribution
€ 463 368,75
Address
Via Bonomea 265
34136 Trieste

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Region
Nord-Est Friuli-Venezia Giulia Trieste
Activity type
Higher or Secondary Education Establishments
Other funding
€ 463 368,75
PERCUROS BV
Netherlands
Net EU contribution
€ 219 375,00
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 219 375,00
NAMLAB GGMBH
Germany
Net EU contribution
€ 496 300,00
Address
Nothnitzer Strasse 64 A
01187 Dresden

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Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 496 300,00
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany
Net EU contribution
€ 399 250,00
Address
Schlossplatz 4
91054 Erlangen

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Region
Bayern Mittelfranken Erlangen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 399 250,00
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain
Net EU contribution
€ 400 506,00
Address
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Other funding
€ 400 506,00
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
Net EU contribution
€ 407 166,00
Address
Via Morego 30
16163 Genova

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Region
Nord-Ovest Liguria Genova
Activity type
Research Organisations
Other funding
€ 407 166,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 402 905,00
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
€ 402 905,00

Partners (1)

UNIVERSITY OF GLASGOW
United Kingdom
Net EU contribution
No data
Address
University Avenue
G12 8QQ Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Other funding
No data