Objective
ReWIRE will combine innovative translational neurotechnologies and rehabilitation interventions for the repair and restoration of neurological functions following injury of the spinal cord (SC). The proposed research program will equip next-generation scientists with unique skills to develop disruptive therapeutic solutions for patients with paralysis. Recent technological breakthroughs have triggered a paradigm shift in the conception of therapies aimed to restore function after spinal cord injury (SCI). Novel drug delivery systems and biomaterial bridges have been engineered to reduce secondary injury and scarring, to stimulate and guide regenerating nerve fibres across the lesion site, and to promote functional reconnection with intact tissue. Additionally, neuromodulation therapies can reactivate spinal circuits below a SCI, allowing people with chronic paralysis to regain voluntary control of walking. In conjunction with rehabilitation, neurological recovery was promoted that persisted without neuromodulation, suggesting a rewiring of the SC as demonstrated in preclinical models. To bypass an injury, neuromodulation has been linked to brain signals to re-establish cortical control over spinal circuits by employing electrical nerve stimulation and robotic systems. Advances in robotics are significantly augmenting the impact of neurorehabilitation by inducing new natural “wired” connections. The aim of ReWIRE is to leverage all these technical and therapeutic breakthroughs in the framework of multiple PhD projects that will continuously interact to converge toward effective combinatorial treatments for SCI. ReWIRE will focus on three inter-woven objectives: i) establish an international, interdisciplinary, and intersectoral educational network, ii) build an SCI clinical data platform, and, iii) position Europe at the forefront of therapy for SCI.
Fields of science
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
52074 Aachen
Germany
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Participants (8)
Participation ended
8243 RC Lelystad
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
21073 Hamburg
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5612 AE Eindhoven
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5656 AE Eindhoven
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
75015 PARIS 15
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56127 Pisa
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56017 Pisa
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
8243 RC LELYSTAD
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (15)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1015 Lausanne
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1011 Lausanne
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8006 Zurich
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
SW7 2AZ LONDON
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
WC2R 2LS London
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
52074 Aachen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1011 JV AMSTERDAM
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
53127 Bonn
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
52499 Baesweiler
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8820 Wadenswil
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
55122 Mainz
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8005 Zurich
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
94607 Berkeley
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
V6T 1Z2 VANCOUVER
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
52062 Aachen
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