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Technology-driven combinatorial therapy to rewire the spinal cord after injury

Objective

ReWIRE will combine innovative translational neurotechnologies and rehabilitation interventions for the repair and restoration of neurological functions following injury of the spinal cord (SC). The proposed research program will equip next-generation scientists with unique skills to develop disruptive therapeutic solutions for patients with paralysis. Recent technological breakthroughs have triggered a paradigm shift in the conception of therapies aimed to restore function after spinal cord injury (SCI). Novel drug delivery systems and biomaterial bridges have been engineered to reduce secondary injury and scarring, to stimulate and guide regenerating nerve fibres across the lesion site, and to promote functional reconnection with intact tissue. Additionally, neuromodulation therapies can reactivate spinal circuits below a SCI, allowing people with chronic paralysis to regain voluntary control of walking. In conjunction with rehabilitation, neurological recovery was promoted that persisted without neuromodulation, suggesting a rewiring of the SC as demonstrated in preclinical models. To bypass an injury, neuromodulation has been linked to brain signals to re-establish cortical control over spinal circuits by employing electrical nerve stimulation and robotic systems. Advances in robotics are significantly augmenting the impact of neurorehabilitation by inducing new natural “wired” connections. The aim of ReWIRE is to leverage all these technical and therapeutic breakthroughs in the framework of multiple PhD projects that will continuously interact to converge toward effective combinatorial treatments for SCI. ReWIRE will focus on three inter-woven objectives: i) establish an international, interdisciplinary, and intersectoral educational network, ii) build an SCI clinical data platform, and, iii) position Europe at the forefront of therapy for SCI.

Coordinator

DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV
Net EU contribution
€ 781 617,60
Address
Forckenbeckstrasse 50
52074 Aachen
Germany

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Research Organisations
Other funding
No data

Participants (7)

PEPSCAN THERAPEUTICS BV
Netherlands
Net EU contribution
€ 274 370,40
Address
Zuidersluisweg 2
8243 RC Lelystad

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Flevoland Flevoland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
TECHNISCHE UNIVERSITAT HAMBURG
Germany
Net EU contribution
€ 260 539,20
Address
Am Schwarzenberg Campus 1
21073 Hamburg

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Region
Hamburg Hamburg Hamburg
Activity type
Higher or Secondary Education Establishments
Other funding
No data
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
Net EU contribution
€ 274 370,40
Address
Groene Loper 3
5612 AE Eindhoven

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Higher or Secondary Education Establishments
Other funding
No data
ONWARD MEDICAL NV
Netherlands
Net EU contribution
€ 274 370,40
Address
High Tech Campus 32
5656 AE Eindhoven

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 282 693,60
Address
Rue Leblanc 25
75015 Paris 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
No data
SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA
Italy
Net EU contribution
€ 259 437,60
Address
Piazza Martiri Della Liberta 33
56127 Pisa

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Region
Centro (IT) Toscana Pisa
Activity type
Higher or Secondary Education Establishments
Other funding
No data
WEARABLE ROBOTICS S.R.L.
Italy
Net EU contribution
€ 259 437,60
Address
Via Nazario Sauro 10 San Giuliano Terme Pi Frazion Tato
56017 Pisa

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Toscana Pisa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data

Partners (15)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
No data
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Other funding
No data
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
Net EU contribution
No data
Address
Rue Du Bugnon 21
1011 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
No data
UNIVERSITAT ZURICH
Switzerland
Net EU contribution
No data
Address
Ramistrasse 71
8006 Zurich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
No data
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
No data
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
No data
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
No data
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITAETSKLINIKUM AACHEN
Germany
Net EU contribution
No data
Address
Pauwelsstrasse 30
52074 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Higher or Secondary Education Establishments
Other funding
No data
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
Net EU contribution
No data
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Other funding
No data
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
Net EU contribution
No data
Address
Venusberg-campus 1/99
53127 Bonn

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Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
No data
Aachen Proteineers GmbH
Germany
Net EU contribution
No data
Address
Arnold-sommerfeld-ring 2
52499 Baesweiler

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
Creoptix AG
Switzerland
Net EU contribution
No data
Address
Zugerstrasse 76
8820 Waedenswil

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Germany
Net EU contribution
No data
Address
Saarstrasse 21
55122 Mainz

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
No data
MYOSWISS AG
Switzerland
Net EU contribution
No data
Address
Hardturmstrasse 135
8005 Zurich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Net EU contribution
No data
Address
Franklin Street 1111 12 Floor
94607 Oakland Ca

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Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITY OF BRITISH COLUMBIA
Canada
Net EU contribution
No data
Address
Agronomy Road 102-6190
V6T1Z1 Vancouver

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Activity type
Higher or Secondary Education Establishments
Other funding
No data
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Germany
Net EU contribution
No data
Address
Templergraben 55
52062 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Higher or Secondary Education Establishments
Other funding
No data