Objective The extremely popular engineering field of drug-eluting biodegradable scaffolds for regenerative medicine, cancer treatment and cardiovascular therapies has largely failed to ensure therapy at the right place, at the right time and with the right dose. Control of actuated drug release is the grand challenge to solve. Previous attempts struggled because, at this time, no technology is able to cope with the influence of scaffold alterations with degradation.MAD Control will establish a multifunctional platform for biodegradable cardiovascular scaffolds and (i) make model-based predictions of degradation states from real-time imaging, (ii) reveal which actuation is best for targeted drug release in the actual degradation state, and (iii) uncover how to generate this actuation.The platform comprises magnetic nanoparticles in hybrid scaffold materials, tailored for a double function: sensors for magnetic particle imaging, and actuators for drug release with magnetic fluid hyperthermia. The imaging results are matched with degradation states based on prediction models to be created, and magnetic fluid hyperthermia is induced in a multimodal device to be developed. Control is achieved by coupling material data streams, acquired through automated and comprehensive in-situ measurements of the hybrid materials’ properties, with modelling and control algorithms.Thus, the multifunctional platform promises a theranostic breakthrough: On-demand release of a precise amount of drugs that can be deliberately chosen. Targeting efficacy is finally measured in vivo, after extensive in-vitro testing.The outcome of this project will be truly transformative, opening new possibilities for research and development of bio¬degradable implants as well as of magnetic transport and release systems for active agents, and it is never limited to cardiovascular applications. Fields of science engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health sciencesclinical medicineoncologyengineering and technologynanotechnologynano-materialsmedical and health sciencesmedical biotechnologyimplants Keywords Magnetic nanoparticles biodegradable hybrid materials magnetic fluid hyperthermia magnetic particle imaging Programme(s) HORIZON.1.1 - European Research Council (ERC) Main Programme Topic(s) ERC-2022-STG - ERC STARTING GRANTS Call for proposal ERC-2022-STG See other projects for this call Funding Scheme HORIZON-ERC - HORIZON ERC Grants Coordinator UNIVERSITAETSKLINIKUM AACHEN Net EU contribution € 1 495 288,00 Address Pauwelsstrasse 30 52074 Aachen Germany See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
