Project description
Understanding head motions’ role in visual processing
Organisms must accurately perceive and interpret their environment for survival. A significant portion of our visual stimuli originates from actions such as head movements, which play a crucial role in contextualising visual information. While the vestibular system reports the motion and orientation of the head in mammals, there is limited knowledge about its connections to visual cortical areas and its impact on behaviour. The ERC-funded SensoMotion project aims to enhance our understanding of how mice process visual information during self-motion. This initiative will delve into the neuronal circuits in the primary visual cortex and address inquiries regarding connectivity, circuit mechanisms and the influence of head motion on visually guided actions. The project will employ advanced techniques for monitoring and regulating circuit activity in a cell-specific manner, neuroanatomical tracing and computational modelling.
Objective
An organisms survival depends on accurately perceiving and interpreting the environment. A significant part of our visual stimulations is however generated by our own actions, rather than external events. For example, the retina can experience similar visual stimulus driven by head-movement, or by a moving object. Therefore, self-motion related information is fundamental to contextualize visual stimuli. In other words, what the eye sees may not be what our brain perceives depending on our actions. In mammals, the vestibular system reports both the motion and orientation of the head. Very little is known about the pathways connecting the vestibular system to visual cortical areas, and how this signal is integrated with external visual stimuli to ultimately impact behaviour. The goal of this project is to unravel the neuronal circuits underlying visual processing during self-motion in mice, thereby providing new insights in sensory processing. To this aim, I will address the following questions: 1) What is the long-range and local connectivity of neurons modulated by head rotation in V1; 2) What are the circuit mechanisms and neuronal computations involved in the integration of self-motion related signals with visual inputs in V1; 3) How do head motion inputs to V1 influence visually-guided actions during behaviour. Achieving these goals relies on a multidisciplinary experimental strategy based on cutting-edge approaches to monitor and control circuit activity with high spatio-temporal resolution in a cell-type specific manner, neuroanatomical tracing, and computational modelling. This experimental strategy combined with my research background in visual and vestibular systems provides a unique opportunity to understand unexplored aspects of sensory processing, at both the cellular and systems levels. Altogether, this project will reveal a novel framework to understand how sensory processing operates during self-motion to guide behaviour.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine ophthalmology
- natural sciences biological sciences zoology mammalogy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-STG
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75794 PARIS
France
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