Periodic Reporting for period 1 - OptiViVax (Optimising a High Efficacy Plasmodium vivax Malaria Vaccine)
Reporting period: 2023-06-01 to 2024-11-30
Plasmodium vivax is the most widespread human malaria with 2.5 billion people living at risk in Africa, South America, Oceania and Asia. The revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria, calling for a vaccine intervention to achieve 75% efficacy over two years, now equally weighted with P. falciparum. However, if this ambition is to be realised, new and innovative approaches are urgently required to accelerate next-generation vaccine research and development, whilst the few known candidate antigens need to undergo early-phase clinical assessment. Here, we build on exciting breakthroughs in P. vivax vaccine research, recently pioneered in Europe, including new transgenic parasite technologies for functional assay development and production of a parasite clone that is safe for use in controlled human malaria infection (CHMI) clinical models. The Objectives of OptiViVax will integrate ambitious multi-disciplinary scientific and clinical approaches around the parasite’s lifecycle and will use our increased knowledge of P. vivax immuno-biology to further develop next-generation vaccines with improved efficacy. We will diversify the portfolio of new antigens ready for clinical testing by reverse vaccinology and diversify their delivery with new platforms and adjuvants developed using sustainable and improved GMP bio-manufacturing know-how. In parallel, the efficacy of known leading antigens will be benchmarked for the first time using innovative design of clinical studies and CHMI models making these lead candidate vaccines ready for future field trials. Improved preclinical functional assays, using state-of-the-art transgenic parasite lines, will also allow for mechanisms of antibody-mediated protection to be deciphered. The availability of new functional assays and human challenge models will underpin the future framework for informed decision making by the clinical vaccine community, policy makers, funders and regulators.
The OptiViVax project’s main aim is to strengthen research on malaria vaccines targeting Plasmodium vivax. In the first 18 months of the project a solid base to identify and test vaccines against vivax malaria was laid:
1. A clinical model to study transmission was established, which will allow testing of vaccines against all P. vivax lifecycle stages using human challenge models.
2. Improved vaccines, adjuvants and application methods are being invented.
3. New methods to study P. vivax parasites and to functionally characterize vaccine candidates are developed and validated.
1. A clinical model to study transmission was established, which will allow testing of vaccines against all P. vivax lifecycle stages using human challenge models.
2. Improved vaccines, adjuvants and application methods are being invented.
3. New methods to study P. vivax parasites and to functionally characterize vaccine candidates are developed and validated.
Nothing to report yet. Will be updated over the course of project.