Project description
Real-time monitoring of AD pathophysiology
Alzheimer’s disease (AD) constitutes the most common form of age-related dementia, and its prevalence is expected to increase, given the rising ageing population. To find effective new treatments, we need to understand the disease-related mechanisms and find ways to monitor them. Funded by the Marie Skłodowska-Curie Actions programme, the FLORIN project proposes an innovative nanotechnology-based bioimaging approach to monitor key mechanisms implicated in AD pathogenesis. Researchers plan to develop a real-time device with temperature biosensing and molecular bioimaging capacity to detect related changes in living tissues. The idea is to advance the diagnosis of AD at an early stage and improve the quality of life of afflicted individuals.
Objective
Since Alzheimer disease (AD) affects up to 50% of individuals above 85, we will witness the three-fold increase in the number of patients by 2050 if no efficient therapy will be found.
The FLORIN offers non-invasive real-time monitoring of key mechanisms involved in the AD pathogenesis by avant-garde bioimaging at temporal resolution less than 1 millisecond and spatial resolution 20 - 50 nm combined with the simultaneous all-optical thermal control with 20 mK accuracy. FLORIN relies on three pillars.
(1) super-resolution optical fluctuation image scanning microscopy (SOFISM) and photon antibunching contrast enhanced super-resolved optical imaging (Q-ISM), providing accurate real-time information on fluorescent nanoparticles delivery, their organelle-specific targeting on the molecular level, and intracellular distribution with spatial resolution below 20-50 nm;
(2) frequency upconverting quantum emitters that enable convert excitation in the tissue transparency window (from 650 to 1350 nm) to fluorescence in visual spectral range;
(3) biosensing techniques capable to detect tiny changes of temperature in the living tissue with 20 mK accuracy.
With its vision for the project and beyond, FLORIN will facilitate the further development of the devices for the clinical diagnosis and treatment of AD, being fully in line with the EU Joint Programme – Neurodegenerative Disease Research and contributing to UN Sustainable Development Goal “To Ensure healthy lives and promote well-being for all at all ages”.
Uniting 6 well-recognized academic partners from EU and Canada, and 3 hi-tech SMEs, ATOMICUS (Germany), Adamas (USA) and Platformina (Lithuania), FLORIN action as a part of the ‘biophotonics and quantum sensing’ flow will contribute to the rise of the potential of individuals and improve their career perspectives in research and innovations within this strongly networked European and global Photonics, Material science, Quantum technologies and Neuroscience communities.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
- medical and health sciences basic medicine neurology dementia alzheimer
- engineering and technology environmental biotechnology biosensing
- natural sciences physical sciences optics microscopy super resolution microscopy
- engineering and technology nanotechnology nano-materials
- engineering and technology nanotechnology nanophotonics
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-SE-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
70211 KUOPIO
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.