Objective
Nowadays a huge amount of planetary DNA and RNA sequencing data is available and continues to double every two years. However, efficiently analyzing this data is impossible due to its size measured in petabases. Many high-impact biological discoveries could be made but are prevented by the lack of fast search algorithms. I recently demonstrated this potential by discovering an order of magnitude more RNA virus species within all public RNA samples. A global index, i.e. a planetary genomic search engine, would unlock instant and inexpensive search within petabase-scale data.
I hypothesize that I can create a searchable index for all of the public DNA and RNA sequencing data. Leveraging my unique expertise across algorithms and data structures for biological sequences, my plan is to design efficient methods to assemble and compress all available sequencing data, and then construct an external-memory index that will support versatile biological queries.
A planetary sequencing data index will enable a myriad of bioinformatics analyses that are currently out of reach. I will demonstrate the utility of the index by constructing a database of human transcripts with novel diseases associations, discovering novel microbial species, and providing a search engine for environmental metagenomes. The resulting unprecedented collection of assembled genomes and compressed reads will lift a major challenge in data accessibility, improving its efficiency by several orders of magnitude, revolutionizing the scale of future bioinformatics analyses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75724 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.