Project description
Innovative X-ray microscope for 3D histology
Non-invasive three-dimensional imaging techniques like computed tomography (CT), ultrasound and magnetic resonance imaging are commonly used in clinical settings for patient diagnosis. However, the gold standard for microscopy of tissue biopsies involves histological procedures involving thin slicing of the tissue before imaging in a microscope, which makes volumetric interpretation challenging. The EU-funded AXES.Histo project aims to develop a prototype X-ray microscope specifically for three-dimensional histology. The project will use a proposed phase-contrast micro-CT scanner to capture 3D images of tissue samples. These images can be rendered by a computer and sliced in any plane, facilitating volumetric data analysis. AXES.Histo will leverage 3D histology to gain insights into the development of lung lesions.
Objective
In the last 20 years, phase-contrast x-ray imaging has evolved from first proof-of-principle experiments with relatively poor contrast, to a mature research field with many branches. Standing on the shoulders of scientific achievements and technological development, the time has come where virtual histology for biomedical applications is within reach. The aim of this research project is to design and construct a prototype x-ray microscope for three-dimensional histology.
In the clinics we are used to non-invasive three-dimensional image modalities such as e.g. computed tomography (CT), ultrasound and magnetic resonance imaging (MRI). The ability to visualise and track structures through a volume is extremely valuable for the purpose of diagnosis.
But for microscopy of tissue biopsies, our golden standard is histological procedures involving thin slicing of the tissue before imaging in a microscope, rendering volumetric interpretation very difficult of not impossible.
With the proposed phase-contrast micro-CT scanner, tissue samples can be imaged in three dimensions such that the computer rendering of the sample can be sliced in any arbitrary plane, and we have the possibility of volumetric data analysis. In this fashion, useful volumetric information can be extracted for various applications in biomedical research.
As a direct application, we will use this 3D Histology setup to obtain detailed volumetric understanding of the development of lung lesions, and complement with gold standard microscopy techniques.
A lab-based setup for virtual histology will allow full studies of disease pathologies with statistical significance and make optimisation of experimental protocols possible.
For achieve the goal of soft tissue micro-CT, we will implement a novel inverse-geometry single-grating interferometer. When combined with state-of-the-art detector and source technology a scanner for high-resolution phase-contrast tomography of soft tissue will be realised.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine pathology
- natural sciences biological sciences histology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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(opens in new window) ERC-2022-COG
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22100 Lund
Sweden
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