Project description
New therapies for chronic lung diseases
The goal of the EU-funded MUC2GO proof-of-concept project is to develop novel therapies for cystic fibrosis, chronic bronchitis, chronic obstructive pulmonary disease (COPD) and other lung diseases presenting with mucus accumulation. The project is based on the previous discovery that a protein that is absent in healthy individuals and animals is found in increased amounts in human COPD and induced lung disease in animal models. This protein forms large polymers by non-covalent interactions and anchors and attaches the lung mucus via cap formation. The current project aims to develop inhibitory peptides, proteins, antibodies and small molecules as therapeutic drugs for detaching the mucus to treat lung diseases with mucus accumulation.
Objective
The aim of this proof of concept is to develop novel therapies based on the discoveries made during the AdvERC grant on mucus and mucins in the lung and intestine. The discovery that the XX protein is absent or almost absent in healthy individuals and animals and heavily increased in human COPD and induced lung disease in animals made us study this. During the ERC grant we discoverd that XX is anchoring and attaching the lung mucus by forming a cap on the accumulated mucus. In the absence of XX the mucus is non-attached and transported even better than normal. We have now determined the detailed molecular structure of the XX and learnt how this protein can form long, large polymers by non-covalent interactions. We will now develop inhibitory peptides, proteins, antibodies or small organic molecules to be used as therapeutic drugs for detaching the attached mucus at Cystic Fibrosis, Chronic bronchitis, COPD, and other lung diseases with mucus accumulation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences polymer sciences
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC2
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
405 30 Goeteborg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.