Objective
Antimicrobial resistance is on the rise and it is predicted to become the first cause of death by 2050. One of the characteristic bacteria phenotypes of antibiotic resistance (and more generally of a stress response) is filamentation, which has been linked to survival strategies and virulence and is present in the most common form of bacteria in nature: biofilms. Thus, characterizing the filamentation phenotype opens the door to understanding the physiology and adaptation of bacterial cells under stress and during colonization processes.
Filamentation results from a coordination of growth and division which are driven by the assembly machinery of the Fts system, the Min oscillatory system, and the nuclear occlusion system. In particular, Fts participates in the septum assembly, a ring-forming cell wall that will separate the daughter cells, whereas the Min oscillatory system restricts the assembly of the division machinery at specific locations to avoid nucleoid cleavage. When bacteria grow regularly, a single septum forms by the middle (symmetric division) to separate the nucleoids of daughter cells. However, when bacteria grow anomalously longer (filamentation), multiple nucleoids continue to segregate along the cell at regular intervals and several putative septa are created. Yet, filamentous bacteria do not grow indefinitely, and division events occur “randomly” (in terms of their timing and the selected septum). This raises the unexplored question of how size is regulated during filamentation processes. In this context, we hypothesize that the interplay between mechanical cues (e.g. filament bending) and changes in the bacteria membrane potential play a key role to regulate bacterial filamentation. Thus, the main objective of this project is determining how mechanosensitive and electrical properties of the division/growth machinery in E. coli regulate its filamentation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.