Objective
Engineering living tissues is expected to revolutionize pharmacological screenings, fundamental biological studies, cruelty-free meat production, and engineered organ replacements. Historically, the functional performance of the living cells within engineered tissues is controlled exclusively via chemical (e.g. growth factors or cell binding peptides) or mechanical (e.g. stiffness/stress relaxation) properties of the biomaterial. All these approaches are united in their shared grand limitation: the cell’s (in)ability and (in)sensitivity to any given signal. This imposes strict design constrictions and associates with donor variation, which has hindered clinical translation and commercial valorisation.
In recent years, it has become known that cell volume dictates sensitivity and responsivity of cells to their microenvironmental cues. Indeed, pathophysiological microenvironments induce alterations in cell volume, which underpins the aetiology of numerous diseases. Although it is anticipated that controlling cellular volumes thus can program the behavior of engineered tissues, especially when implanted in diseased sites, currently no strategy to realize this in 3D tissues is available.
This proposed VoluFaTE project aims to leverage a cutting-edge single-cell microgel technology to overcome this grand challenge by providing the world’s first platform to program cell volume in a scalable, widely-applicable, and translatable manner. Healing of cartilage defects is chosen as a model system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- engineering and technology mechanical engineering
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7522 NB Enschede
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.