Project description
Waveguide-based miniaturised optical cochlear implant
The optical cochlear implant (oCI) represents an innovative approach to restoring near-natural hearing by directly stimulating the auditory nerve with light. It leverages micro-scale light emitter technology and optogenetics to replace dysfunctional or missing hair cells. Seeking to improve these devices, the EU-funded OptoWave project will assess the feasibility of miniaturising and integrating optical components for future cochlear implants. The project will employ micro-scaled waveguide arrays and multi-beam laser diode emitters, with preclinical validation conducted in rodents. The proposed optical module employs waveguides and boasts several features that render it suitable for clinical applications. Importantly, the optical emitters can be safely integrated into a hermetically sealed titanium package, thereby reducing the risk of heat affecting the patient during visual stimulation.
Objective
The optical cochlear implant (oCI) aims to restore near natural hearing in profoundly hearing impaired and deaf patients. Sound perception will be restored through an implantable medical device in combination with a gene therapy medicinal product. Thereby the auditory nerve is stimulated directly through focused light replacing the dysfunctional or absent hair cells. This is achieved through combination of micro-scale light emitter technology and precise neural control through expression of light-gated ion channels in the auditory nerve (called optogenetics).
Here, we propose to prove feasibility of an optical waveguide modules for future optical cochlear implants. Building on fabricating micro-scaled waveguide arrays, multi-beam laser diode emitters, we plan to couple them via micro-lens arrays in a compact multi-channel optical module for testing the feasibility of miniaturization and integration of the optical components. Preclinical validation shall be performed in rodents.
The proposed waveguide-based optical module combines several aspects, which makes it a candidate for later clinical application. The optical emitters can be safely integrated in the hermetically sealed titanium package housing the internal oCI electronics. Thus, there is no need to directly insert the emitters in the cochlear turns, which mitigates the risk of heat impact on the patient during optical stimulation. Furthermore, emerging red light activated opsins can be addressed by readily available red laser diode technology.
Fields of science
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural scienceschemical sciencesinorganic chemistrytransition metals
- medical and health sciencesmedical biotechnologyimplants
- natural sciencesphysical sciencesopticslaser physics
Keywords
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Funding Scheme
HORIZON-ERC-POC - HORIZON ERC Proof of Concept GrantsHost institution
37075 Goettingen
Germany