Project description
Stem cell-based treatment of corneal blindness
Differentiation of corneal limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) represents a promising treatment for ocular surface reconstruction and corneal epithelial renewal in cases of corneal blindness. However, a lack of understanding regarding the true LSC population identity and homeostasis regulation prevents the development of therapies based on hPSC-derived LSCs. StemSight, based in Finland, is developing off-the-shelf stem cell therapies to cure blindness. The company aims to develop strategies to solve the global shortage of corneal donor tissue by producing tissue products using induced pluripotent stem cells and biomaterials. The goal of the EU-funded SightLeaders project is the identification of the specific markers and maintenance of the clinically relevant LSC population.
Objective
StemSight is developing off-the-shelf stem cell therapies to cure blindness. We aim to solve the global shortage of corneal donor tissue by producing high-quality tissue products using allogeneic induced pluripotent stem cells (iPSCs) and biomaterials. Our lead product is aimed at a rare but severe form of corneal blindness, limbal stem cell deficiency (LSCD), for which there are currently no valid treatment options. The company's innovations have arisen from extensive academic research, and the company has spun out from Tampere University, Finland in 2021. StemSight is a rare kind of deep-tech startup, as all of its scientific founders are women.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.2 - European innovation ecosystems
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-CSA - HORIZON Coordination and Support Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIE-2022-SCALEUP-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
33520 Tampere
Finland
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.