Project description
Exploring IgG4-autoimmune diseases for new treatment strategies
IgG4-autoimmune diseases (IgG4-AIDs) are rare but can seriously affect organs such as the skin, brain, nerves and kidneys. Many patients are unresponsive to current treatments. These diseases involve immune dysfunction and the production of harmful IgG4 antibodies that disrupt normal body functions. With the support of the Marie Skłodowska-Curie Actions programme, the IgG4-TREAT project will explore IgG4-AIDs by studying pathogenic IgG4 and the mechanisms of autoantibody production. It will create a humanised mouse model for testing a novel immune-apheresis therapy. The programme will combine university education with multidisciplinary training, preparing experts for careers in academia and industry, with a focus on digitalisation and sustainable research to tackle challenges such as climate change and social inequalities.
Objective
IgG4-autoimmune diseases (IgG4-AID) are rare but collectively correspond to a significant group of devastating diseases affecting
many different organs, e.g. skin, brain, nerves and kidney in patients that often remain unresponsive to current treatments. IgG4-AID
have commonalities indicating a shared underlying immunopathogenesis that make a joint approach to identify new therapeutic
targets and test new treatment strategies feasible and necessary. We hypothesize that genetic risk factors and a dysregulated
immune response may lead to an increased susceptibility to produce antibodies targeting self-proteins. These are of a special
subclass called IgG4, which are usually harmless but can cause disease in these patients by interfering with normal functions in the
body. We are the first consortium that aims to study IgG4-AID comparatively, including pathogenic IgG4, and the cells, molecules and
mechanisms involved in IgG4 autoantibody production, using an explorative multi-omics approaches in combination with state-ofthe-
art cell and molecular biology methodology. We will establish a new humanized mouse model of IgG4-AID for the development
and testing of a novel immune-apheresis based therapy aimed as immediate relief therapy for all IgG4-AID patients. Our innovative
training program combines university-based and multidisciplinary research-based training with state-of the art web-based training
and in-person trainings by the academic and non-academic sector. We aim to foster a new generation of experts in IgG4-AID that are
1) are highly employable both in the academic and industry sectors and qualified for innovative multidisciplinary translational
research with a focus on biomedical product development and 2) equipped with the skillsets for digitalization, awareness for gender
equality and diversity and competent in sustainable research and innovation approaches to address current and future challenges,
such as climate change, social inequalities and pandemics.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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(opens in new window) HORIZON-MSCA-2022-DN-01
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1090 Wien
Austria
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Participants (8)
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75654 Paris
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23562 Lübeck
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2333 ZA Leiden
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34452 Istanbul
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1006 AN Amsterdam
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10117 Berlin
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6200 MD Maastricht
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115 23 Athens
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Partners (11)
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105 61 ATHINA
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115 21 ATHENS
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27100 Pavia
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24118 Kiel
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56123 Pisa
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1012WX Amsterdam
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75006 Paris
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601 77 Brno
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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24105 Kiel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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56126 Pisa
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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08036 Barcelona
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