Objective Cancer is one of the major causes of death in Europe. Pancreatic (PC) and biliary tract (BTC) cancer are rare gastrointestinal adenocarcinomas with an increasing incidence particularly among the elderly and women in an ageing European population, and a poor prognosis poses major clinical challenges and public health burden. Cold atmospheric pressure plasma (CAP) has shown potential regressing various cancer types in the laboratory setting. Owing to their properties, CAP is a unique source of high concentrations of reactive radicals, electrons, ions, UV etc. that may induce various effects in living tissue. CAP has shown selectivity in where cancer cells are treated with minimal effect to healthy ones; this renders plasma suitable to treat carcinomas in very sensitive areas or organs where an unmet need to minimise damage/side-effects exists. CAP can be delivered through dielectric tubes of variable length, which makes it ideal for minimally invasive and precise laparoscopic and endoscopic operations. Despite the great promise and potential of this concept, there is no single laparoscopic or endoscopic medical platform in the market today based on CAP to treat carcinomas. This project proposes a novel solution using cutting-edge plasma technology, in-silico models, and a system-level approach. It will combine plasma with tumour multiscale simulations and will take input from pre-surgery diagnostics for in-silico model initialisation and CAP operational window determination. The developed technology will be demonstrated through in-vivo experiments, while the foundations for clinical trials and market introduction for CAP-based care of PC/BTCs will be laid out in this project. Fields of science medical and health sciencesclinical medicineoncologyprostate cancermedical and health scienceshealth sciencespublic healthnatural sciencesphysical sciencesplasma physicsnatural sciencescomputer and information sciencescomputational sciencemultiphysics Keywords surgical instrument medical device cancer removal cold plasma multiscale model multiphysics model simulation in silico personalised treatment Programme(s) HORIZON.3.1 - The European Innovation Council (EIC) Main Programme Topic(s) HORIZON-EIC-2023-PATHFINDEROPEN-01-01 - EIC Pathfinder Open Call for proposal HORIZON-EIC-2023-PATHFINDEROPEN-01 See other projects for this call Funding Scheme HORIZON-EIC - HORIZON EIC Grants Coordinator UNIVERSITY OF CYPRUS Net EU contribution € 825 000,00 Address AVENUE PANEPISTIMIOU 2109 AGLANTZI 1678 Nicosia Cyprus See on map Region Κύπρος Κύπρος Κύπρος Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 825 000,00 Participants (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all SORBONNE UNIVERSITE France Net EU contribution € 1 193 750,00 Address 21 RUE DE L'ECOLE DE MEDECINE 75006 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 193 750,00 PANEPISTIMIO PATRON Greece Net EU contribution € 773 750,00 Address UNIVERSITY CAMPUS RIO PATRAS 265 04 Rio Patras See on map Region Κεντρική Ελλάδα Δυτική Ελλάδα Αχαΐα Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 773 750,00 Partners (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all OGKOLOGIKO KENTRO TRAPEZAS KYPROU Cyprus Net EU contribution € 0,00 Address LEOFOROS AKROPOLEOS 32 2006 STROVOLOS See on map Region Κύπρος Κύπρος Κύπρος Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data SYNNOUS LIMITED United Kingdom Net EU contribution € 0,00 Address 152A HARPENDEN ROAD, ST ALBANS AL3 6BZ HERTFORDSHIRE See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region East of England Bedfordshire and Hertfordshire Hertfordshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
