Project description
Revolutionary biopolymer advances in post-surgical healing
Advancements in post-surgical healing are a major focus in biomedical science, necessitating innovations in materials science. Current medical glues, while more efficient than traditional sutures, still lack sufficient wet-tolerant adhesive strength. Biopolymers, being naturally derived and biocompatible, present enormous potential for such applications as tissue glue. However, developing a biopolymer with the required adhesive properties remains a challenge. With the support of the Marie Skłodowska-Curie Actions programme, the GEMSilk project will develop a new type of tissue glue using genetically engineered silk from silkworms. By incorporating glue motifs via CRISPR/Cas9, GEMSilk aims to produce commercial quantities of wet-tolerant silk glue. This interdisciplinary effort combines silk analysis and genetic engineering.
Objective
Advancements in post-surgical healing are a major topic in biomedical science and require innovations in materials science. In many medical procedures, current medical glues are more efficient than traditional sutures but they still lack sufficient wet-tolerant adhesive strength. Biopolymers are naturally derived and biocompatible, and present enormous potential for applications such as tissue glue. To address the adhesive challenge, we propose GEMSilk, an innovative and interdisciplinary framework integrating analytical techniques of material science with genetically engineered silk glue. Our key objective is to develop a caddisfly-derived and inherently wet-tolerant aquatic silk glue recombinant protein expression system in the domestic silkworm (Bombyx mori). Utilising CRISPR/Cas9, caddisfly aquatic silk glue DNA motifs will be inserted into the silkworm's silk gene, the resulting stable mutant lines will produce commercial quantities of wet-tolerant silk glue. By training through research and a secondment at the lab of supervisor Seib’s collaborator, I will gain essential, state-of-the-art skills in novel silk biopolymer design and silk analysis. Moreover, the silk glue product will undergo intellectual property evaluations with Seib, further augmenting my professional skill set with this essential process and the potentials beyond GEMSilk will also be assessed.
During GEMSilk, I will gain substantial and rigorous training in silk analysis and essential assays for silks based healthcare. I will be located at Fraunhofer-IME's new world-class multi-disciplinary applied insect biotechnology research institute. Over the past months, Seib and I have honed GEMSilk. Combining Seib’s profound experience in silk analysis for healthcare with my skills in silkworm genetic engineering, not only promises to elevate my career through advanced training and project management but also to develop a game-changing silk-based product for biomedical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences zoology entomology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80686 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.