Project description
Assessing hyperarousal symptoms in post-traumatic stress disorder
Up to 70 % of people experience a traumatic event, and 10-15 % go on to develop post-traumatic stress disorder (PTSD). Despite treatment, around 40 % continue to suffer from hyperarousal symptoms such as irritability and sleep disturbances. The cognitive mechanisms underlying these symptoms remain poorly understood. Supported by the Marie Skłodowska-Curie Actions programme, the HYPE project will investigate the cognitive processes linked to hyperarousal, examining the roles of gender and repeated trauma. It will also assess how these processes influence the development of other PTSD symptoms over time. By combining eye-tracking, electroencephalography, and machine learning, the project aims to deliver precise assessments and identify new therapeutic targets to improve patient outcomes.
Objective
Up to 70% of people will experience a traumatic event in their lives. Following such events, post-traumatic stress disorder (PTSD) emerges as the most common adverse psychological consequence, affecting 10-15% of survivors. Despite available therapies, nearly 40% of patients continue to exhibit hyperarousal symptoms such as irritability, risk-taking behaviors, sleep disturbances, concentration difficulties, and an enhanced startle response. Several cognitive processes (e.g. attentional biases, emotion recognition, executive functioning) have been investigated to understand the mechanisms behind isolated hyperarousal symptoms, such as hypervigilance or startle responses. However, the exact nature and mechanisms through which these cognitive processes influence the whole spectrum of hyperarousal symptoms remain largely unknown. In response, the HYPE project aims to: (1) offer the first comprehensive evaluation of the cognitive processes underlying various hyperarousal symptoms, (2) examine the effects of gender and repeated traumatization on these processes, and (3) longitudinally assess the predictive value of these cognitive processes on the development and persistence of other PTSD symptoms. By utilizing eye-tracking (ET), electroencephalography (EEG) and machine learning techniques, these studies will provide precise and reliable assessments of these intricate cognitive processes and highlight new therapeutic targets with direct benefits for patients. While both the host-lab and myself are specialized in PTSD, the synergy between the host lab's expertise in EEG and affective neurosciences, and my knowledge of ET and advanced statistical methods, makes this ambitious project mutually beneficial. Complementarily, the training activities planned will not only improve my research skills but also my independence, mentoring, and communication abilities, preparing me for a young leader position able to transfer knowledge to both specialized and not-specialized audience.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine psychiatry posttraumatic stress disorder
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2023-PF-01
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59000 Lille
France
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