Objective
Spontaneous brain activity as assessed with resting-state fMRI (rsfMRI) is increasingly used as an index of interregional brain
communication and functional connectivity in health and disease. However, the physiological underpinnings of brain-wide rsfMRI
coupling, and the neural effectors of its dynamic reconfiguration, remain undetermined. Recent investigations, including my own
work, have crucially shown that rsfMRI large-scale activity in the mammalian brain is critically shaped by a limited set of recurrent
wave-like spatiotemporal patterns. Further investigations by us and others point at a putative link between global patterns of brain
activity and fluctuations in internal states linked to arousal. These observations suggest that the dynamics and specific spatial
topography of rsfMRI network dynamics could be critically shaped by the intrinsic activity of ascending neuromodulatory systems like
Acetylcholine (ACh) or Noradrenaline (NA). This project aims to formally test this hypothesis via a first-of-its-kind multiscale,
multimodal investigation of whole-brain rsfMRI activity and intrinsic neurotransmitter function as assessed with mesoscopic imaging
of genetically-encoded ACh and NA fluorescent sensors in the awake mouse brain. To causally link these two phenomena, I will
systematically modulate general arousal levels, and probe neurotransmitter specificity via pharmacological and chemogenetic
manipulations. Importantly, dual-color mesoscale calcium and ACh or NE imaging will be coupled to rsfMRI mapping to disentangle
the tripartite relationship between local and global neuromodulatory tone, neural activity, and network dynamics. These studies will
shed light on the neural drivers and functional significance of rsfMRI signal, with important implications for the use of this method to
map functional connectivity in health and disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences computer and information sciences artificial intelligence computational intelligence
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
16163 GENOVA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.