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Magnesium and fetal metabolic programming: an approach to preventing a life-cycle of metabolic diseases

Project description

From mother to offspring: disrupted magnesium metabolism

Magnesium is a nutrient needed for many reasons, including regulating muscle and nerve function, blood sugar levels and blood pressure as well as making protein, bone and DNA. During pregnancy, magnesium needs increase, and insufficiency can affect the mother and foetus. Obesity patients with type 2 diabetes often have a magnesium deficiency. Furthermore, obesity and type 2 diabetes increase the risk of complication during pregnancy and affect offsprings’ health through developmental programming effects. With the support of the Marie Skłodowska-Curie Actions programme, the MagFetProg project will investigate changes in maternal liver metabolism related to magnesium levels and signalling, their effect on the maternal metabolic state and any negative impact on the developing foetus.

Objective

Obesity prevalence is increasing as well as the related metabolic alterations. Obesity and T2D increase the risk of pregnancy complication and affect offspring health through developmental programming effects. Obese patients with T2D frequently present Mg2+ deficiency. During pregnancy, Mg2+ needs increases, and its insufficiency may affect the mother and fetus, interfering with pregnancy development and offspring growth. Although it is known the relevance of Mg2+, its role in pregnancy is often overlooked and the underlying mechanisms that causes disturbances on Mg2+ homeostasis are unelucidated. Mg2+ homeostasis is carefully regulated. Among the channels are the cyclin M 1-4 (CNNM1-4), highly conserved molecules. Although it has been suggested that Mg2+ transport and homeostasis plays a key role in development, its regulation during development and in maternal-fetal communication is not fully understood. Fetal growth is closely related to the placenta capacity to transport nutrients and ions. At birth, the fetus makes a transition from using placental nutrient supply to utilize the liver. Thus, changes in maternal liver metabolism related to Mg2+ levels and signalling could affect the maternal metabolic state and negatively impact the developing fetus. This project aims to assess the role of Mg2+ homeostasis and transport through the CNNMs in programming effects in the context of maternal T2D and obesity. We will focus on the role of Mg2+ on fetal programming effects in a context of altered maternal metabolism and to evaluate the impact on offspring liver. In addition, we will evaluate the potential dietary intervention with Mg2+ supplementation for ameliorating offspring-derived effects. We hypothesize that maternal obesity leads to an altered environment that involves an impaired maternal hepatic Mg2+ signaling through the CNNMs that affects the metabolic fetal environment and the maternal-fetal interaction and programs offspring metabolic alterations.

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HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

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(opens in new window) HORIZON-MSCA-2023-PF-01

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Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 181 152,96
Address
PARQUE TECNOLOGICO EDIFICIO 801 A
48160 DERIO VIZCAYA
Spain

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
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