Objective
Despite its high prevalence (10% of women and those assigned female at birth; 200 million worldwide) and huge patient and socioeconomic burden (30 billion annually on sick leave in the EU), endometriosis is one of the least researched and most underfunded diseases. Decades of indifference and neglect, gaps in our understanding of its aetiology and diagnosis, inadequate therapeutic approaches to pain and infertility, and relatively high uptake of unproven self-management strategies characterise the disease. Using a multipronged approach, our project aims to address critical unmet clinical needs around endometriosis. With involvement of patient organisations and patients with diverse real-life experiences across Europe, we will explore how patients perceive self-management in the light of existing stigma and dismissal in clinical interactions. We will conduct a randomised controlled trial to evaluate the effectiveness of dietary intervention and cognitive behavioural therapy on endometriosis-related pain and subfertility, aiming at developing new treatment options and practical tools. Analysing steroid metabolomics and microRNA profiling will provide a powerful diagnostic approach able to predict the effectiveness of interventions and likelihood of recurrence, while investigating the link between microbiota health, local epigenetic alterations, immune response and endometriosis development will yield a better understanding of disease mechanisms. Utilising eHealth-based technologies and AI/machine learning, we will also develop models that can predict responses to lifestyle behaviours. Project outcomes will empower affected patients to make and shape decisions for their own health, educate the general public about endometriosis and its heavy burden, and reduce stigmatisation, encouraging more individuals to seek help.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.3 - Non-Communicable and Rare Diseases
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2024-DISEASE-03-two-stage
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1348 LOUVAIN LA NEUVE
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.