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Method for Integrated All-Optical Biological Analysis at Scale

Objective

The advent of light-emitting sensors and light-driven actuators has profoundly transformed the fields of biology and medical science over the past three decades. These innovations enable the manipulation and monitoring of various physiological processes using light with remarkable precision in both time and space. Applications include the study of signaling and cell trafficking in healthy and malignant tissues, the unraveling of causal relationships within neural networks or the assessing the effects of pharmaceutical compounds. To fully harness the potential of these so-called optogenetic technologies, there is a pressing need to create integrated optical systems offering both 3D imaging and precise light-targeting of specific regions at scale. Within the framework of the ERC, we have successfully engineered a unique system designed for the optogenetic probing of small vertebrate brains (zebrafish larvae) at cellular resolution. Our proposal expands upon this earlier achievement, by evolving it into a versatile all-optical platform tailored for biologists and biomedical laboratories. This platform will seamlessly integrate cutting-edge optical systems with automated data analysis through artificial intelligence (AI) techniques. Anticipating a vast array of applications, we envision that this platform will prove invaluable e.g. in the realms of neuroscience, developmental biology, and cancer research. Its multifaceted capabilities will empower researchers to unlock new insights and accelerate advancements in these critical scientific domains.

Fields of science (EuroSciVoc)

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Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2023-POC

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Host institution

SORBONNE UNIVERSITE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 150 000,00
Address
21 RUE DE L'ECOLE DE MEDECINE
75006 PARIS
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Beneficiaries (1)

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