Project description
Advanced cortical fibre visualisation to understand neurodegenerative processes
Magnetic resonance imaging (MRI) is essential for understanding brain activity and disease. Diffusion MRI (dMRI) aids in reconstructing the connections between brain areas, but it cannot reveal the internal wiring of the cortex, where cognitive functions occur, in living humans. The ERC-funded BRACE project will non-invasively map the brain’s cortical fibres associated with neurodegenerative processes and cognitive decline. The project combines dMRI with MR relaxometry and a specialised signal model to characterise axonal fibres in the cortex. Advanced hardware and super-resolution techniques will enhance in vivo MRI capabilities, enabling the visualisation of cortical fibres in living humans and facilitating the exploration of their properties in Alzheimer’s patients, changes during ageing and their relationship with cognitive function.
Objective
MRI provides the unique opportunity to investigate the relation between brain structure and function non-invasively, which is key to understand the functioning of the brain and unravel disease processes. An important technique is diffusion MRI (dMRI), which allows to reconstruct the structural connections through which brain structures communicate. Conversely, no technique can reconstruct the internal wiring of brain structures such as the cortex in living humans, where cognitive functions are processed, hindering scientific and societal progress. To achieve this, three challenges must be overcome: a spatial gap of an order of magnitude between (d)MRI and the cortical circuitry; insufficient contrast provided by (d)MRI in the cortex; and a lack of appropriate models to characterize cortical circuits.
I aim to bridge the gap between structure and function by mapping the fibers of the brain cortex non-invasively for the first time, which are expected to be affected by neurodegenerative processes, and to be closely related to cognitive decline. To achieve this goal, I will pioneer a synergistic approach combining my expertise (dMRI acquisition and modelling), with unique acquisition hardware designed at our institution.
First, I will establish a novel multidimensional acquisition combining dMRI with MR relaxometry, together with a signal model tailored to characterize axonal fibers in the cortex. Next, I will leverage state-of-the-art hardware and super-resolution approaches to push the boundaries of in-vivo MRI by an order of magnitude (to the mesoscale). This will unveil cortical fibers in living humans for the first time, and allow us to explore their properties in patients with Alzheimer’s disease, their changes during ageing, and their relationship with cognitive function. Altogether, we will provide a new asset to understand cognitive dysfunction in neurodegeneration, and generate novel fundamental insights for systems neuroscience.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciencesbiological sciencesneurobiology
- engineering and technologymaterials engineeringfibers
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- natural sciencesphysical sciencesopticsmicroscopysuper resolution microscopy
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Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Topic(s)
Funding Scheme
HORIZON-ERC - HORIZON ERC GrantsHost institution
3584 CX Utrecht
Netherlands